deltatrials
Terminated PHASE2 INTERVENTIONAL 1-arm NCT03708003

Ibrutinib lead-in Followed by Venetoclax Plus Ibrutinib in Patients With RR CLL

Ibrutinib lead-in Followed by Venetoclax Plus Ibrutinib in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia. A Multicenter, Open-label, Phase II Trial

Sponsor: Swiss Cancer Institute

Updated 20 times since 2018 Last updated: Dec 23, 2025 Started: Mar 11, 2019 Primary completion: Nov 30, 2025 Completion: Nov 30, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

The board decision has been made to conclude the trial ahead of schedule. The primary endpoint has been successfully achieved and published, and funding was secured to support these three years of followup.

This PHASE2 trial investigates Chronic Lymphocytic Leukemia and Leukemia and is currently terminated or withdrawn. Swiss Cancer Institute leads this study, which shows 20 recorded versions since 2019 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Nov 2018 – ~Mar 2019 · 4 months · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Mar 2020 · 10 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Sep 2020 · 5 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Jun 2021 · 5 months · monthly snapshot~Jun 2021 – ~Oct 2021 · 4 months · monthly snapshot~Oct 2021 – ~Dec 2021 · 2 months · monthly snapshot~Dec 2021 – ~Apr 2022 · 4 months · monthly snapshot~Apr 2022 – ~May 2023 · 13 months · monthly snapshot~May 2023 – ~May 2024 · 12 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~May 2025 · 8 months · monthly snapshot~May 2025 – ~Aug 2025 · 3 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Jan 2026 · 4 months · monthly snapshot~Jan 2026 – present · 8 months · monthly snapshot

Change History

20 versions recorded
  1. Jan 2026 — Present [monthly]

    Terminated PHASE2

    Status: Active Not RecruitingTerminated

  2. Sep 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

  4. May 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Sep 2024 — May 2025 [monthly]

    Active Not Recruiting PHASE2

Show 15 earlier versions
  1. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  2. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  3. May 2023 — May 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Apr 2022 — May 2023 [monthly]

    Active Not Recruiting PHASE2

  5. Dec 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE2

  6. Oct 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE2

  7. Jun 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE2

  8. Jan 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE2

  9. Sep 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  10. Apr 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  11. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  12. May 2019 — Mar 2020 [monthly]

    Recruiting PHASE2

  13. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2

  14. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  15. Nov 2018 — Mar 2019 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Swiss Cancer Institute
Data source: Swiss Cancer Institute

For direct contact, visit the study record on ClinicalTrials.gov .