deltatrials
Active Not Recruiting PHASE3 INTERVENTIONAL 2-arm NCT03732677

Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC (NIAGARA)

A Phase III, Randomized, Open-Label, Multi-Center, Global Study to Determine the Efficacy and Safety of Durvalumab in Combination With Gemcitabine+Cisplatin for Neoadjuvant Treatment Followed by Durvalumab Alone for Adjuvant Treatment in Patients With Muscle-Invasive Bladder Cancer.

Sponsor: AstraZeneca

Conditions Muscle Invasive Bladder Cancer
Interventions Cisplatin Durvalumab Gemcitabine
Updated 51 times since 2018 Last updated: Feb 23, 2026 Started: Nov 16, 2018 Primary completion: Apr 29, 2024 Completion: Jun 30, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03732677, this PHASE3 trial focuses on Muscle Invasive Bladder Cancer and remains ongoing. Sponsored by AstraZeneca, it has been updated 51 times since 2018, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Jan 2020 · 2 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Feb 2022 · 4 months · monthly snapshot~Feb 2022 – ~May 2022 · 3 months · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Mar 2023 · 3 months · monthly snapshot~Mar 2023 – ~Jul 2023 · 4 months · monthly snapshot~Jul 2023 – ~Oct 2023 · 3 months · monthly snapshot~Oct 2023 – ~Jan 2024 · 3 months · monthly snapshot~Jan 2024 – ~Apr 2024 · 3 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Dec 2024 · 2 months · monthly snapshot~Dec 2024 – ~Mar 2025 · 3 months · monthly snapshot~Mar 2025 – ~Aug 2025 · 5 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – ~Mar 2026 · 3 months · monthly snapshot~Mar 2026 – present · 6 months · monthly snapshot

Change History

51 versions recorded

  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE3

  2. Dec 2025 — Mar 2026 [monthly]

    Active Not Recruiting PHASE3

  3. Sep 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Mar 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE3

▶ Show 46 earlier versions

  1. Dec 2024 — Mar 2025 [monthly]

    Active Not Recruiting PHASE3

  2. Oct 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE3

  3. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE3

  4. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  5. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE3

  6. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  7. Jan 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE3

  8. Oct 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE3

  9. Jul 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE3

  10. Mar 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE3

  11. Dec 2022 — Mar 2023 [monthly]

    Active Not Recruiting PHASE3

  12. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE3

  13. Jun 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  14. May 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE3

  15. Feb 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE3

  16. Oct 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  17. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE3

  18. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  19. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE3

  20. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE3

  21. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE3

  22. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  23. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  24. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  25. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE3

  26. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE3

  27. Aug 2020 — Oct 2020 [monthly]

    Recruiting PHASE3

  28. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE3

  29. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE3

  30. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE3

  31. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE3

  32. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE3

  33. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE3

  34. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE3

  35. Nov 2019 — Jan 2020 [monthly]

    Recruiting PHASE3

  36. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE3

  37. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  38. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE3

  39. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  40. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  41. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

  42. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE3

  43. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE3

  44. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE3

  45. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  46. Dec 2018 — Jan 2019 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Nov 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AstraZeneca
Data source: AstraZeneca

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Amsterdam, Netherlands , Angers, France , Ankara, Turkey (Türkiye) , Ann Arbor, United States , Antofagasta, Chile , Badalona, Spain , Baguio City, Philippines , Barcelona, Spain , Bari, Italy , Barretos, Brazil and 152 more locations