deltatrials
Completed PHASE2 INTERVENTIONAL 5-arm NCT03772587

A Study to Evaluate the Safety, Tolerability, Efficacy, Pharmacokinetics and Pharmacodynamics of M281 Administered to Adults With Generalized Myasthenia Gravis

A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Efficacy, Pharmacokinetics and Pharmacodynamics of M281 Administered to Adults With Generalized Myasthenia Gravis

Sponsor: Momenta Pharmaceuticals, Inc.

Conditions Generalized Myasthenia Gravis
Interventions M281 Placebo
Updated 22 times since 2019 Last updated: Jun 6, 2023 Started: Apr 10, 2019 Primary completion: Jun 25, 2020 Completion: Jun 25, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Generalized Myasthenia Gravis and is currently completed. Momenta Pharmaceuticals, Inc. leads this study, which shows 22 recorded versions since 2019 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Aug 2019 · 2 months · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Dec 2019 · 2 months · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Oct 2020 · 6 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Nov 2021 · 7 months · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jul 2023 · 19 months · monthly snapshot~Jul 2023 – ~Jul 2024 · 12 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

22 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. Jul 2023 — Jul 2024 [monthly]

    Completed PHASE2

  5. Dec 2021 — Jul 2023 [monthly]

    Completed PHASE2

▶ Show 17 earlier versions

  1. Nov 2021 — Dec 2021 [monthly]

    Completed PHASE2

  2. Apr 2021 — Nov 2021 [monthly]

    Completed PHASE2

  3. Jan 2021 — Apr 2021 [monthly]

    Completed PHASE2

  4. Oct 2020 — Jan 2021 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  5. Apr 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  6. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  7. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  8. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2

  9. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  10. Oct 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  11. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  12. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  13. Jun 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  14. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  15. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2

  16. Feb 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  17. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Momenta Pharmaceuticals, Inc.
Data source: Momenta Pharmaceuticals, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Antwerp, Belgium , Augusta, United States , Aurora, United States , Austin, United States , Badalona, Spain , Barcelona, Spain , Birmingham, United Kingdom , Boca Raton, United States , Boston, United States , Brussels, Belgium and 46 more locations