deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT00278421

Rituximab and Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma

Randomized Study Comparing 4 and 6 Cycles of Chemotherapy With CHOP (Cyclophosphamide, Doxorubicin, Vincristine and Prednisone) at 21-day Intervals, Both With 6 Cycles of Immunotherapy With the Monoclonal Anti-CD20-Positive B-Cell Lymphoma Aged 18-60 Years Having no Risk Factor (Age-Adjusted IPI=0) and No Large Tumor Mass (Diameter <7,5cm) [FLYER 6-6-6-4 Study]

Sponsor: German High-Grade Non-Hodgkin's Lymphoma Study Group

Conditions Lymphoma
Updated 9 times since 2017 Last updated: Mar 9, 2021 Started: Nov 30, 2005 Primary completion: Aug 31, 2018 Completion: Aug 31, 2018
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Lymphoma and is currently completed. German High-Grade Non-Hodgkin's Lymphoma Study Group leads this study, which shows 9 recorded versions since 2005 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Jun 2018 · 17 months · monthly snapshotCompleted~Jun 2018 – ~Apr 2019 · 10 months · monthly snapshotCompleted~Apr 2019 – ~May 2019 · 30 days · monthly snapshotCompleted~May 2019 – ~Jan 2021 · 20 months · monthly snapshotCompleted~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshotCompleted~Apr 2021 – ~Jul 2024 · 39 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotCompleted~Sep 2025 – present · 8 months · monthly snapshotCompleted

Change History

9 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. Apr 2021 — Jul 2024 [monthly]

    Completed PHASE3

  5. Jan 2021 — Apr 2021 [monthly]

    Completed PHASE3

Show 4 earlier versions
  1. May 2019 — Jan 2021 [monthly]

    Completed PHASE3

  2. Apr 2019 — May 2019 [monthly]

    Completed PHASE3

  3. Jun 2018 — Apr 2019 [monthly]

    Completed PHASE3

  4. Jan 2017 — Jun 2018 [monthly]

    Completed PHASE3

    First recorded

Nov 2005

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • German High-Grade Non-Hodgkin's Lymphoma Study Group
Data source: German High-Grade Non-Hodgkin's Lymphoma Study Group

For direct contact, visit the study record on ClinicalTrials.gov .