deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 1-arm NCT03789240

Response-Adapted Therapy With Copanlisib and Rituximab in Untreated Follicular Lymphoma

A Phase 2 Study of Response-Adapted Therapy With Copanlisib and Rituximab in Untreated Follicular Lymphoma

Sponsor: National Cancer Institute (NCI)

Conditions Follicular Lymphoma NHL Non-Hodgkin's Lymphoma
Interventions 18F-FDG-PET/CT Scan15 Bone Marrow Aspiration/Biopsy CT Scans Copanlisib Electrocardigram Rituximab
Updated 70 times since 2019 Last updated: Feb 13, 2026 Started: Aug 22, 2019 Primary completion: Sep 24, 2025 Completion: Jan 1, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Follicular Lymphoma and NHL and is currently ongoing. National Cancer Institute (NCI) leads this study, which shows 70 recorded versions since 2019 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Jan 2022 · 2 months · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Feb 2023 · 3 months · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jul 2023 · 2 months · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Dec 2023 · 2 months · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Apr 2025 · 3 months · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – ~Mar 2026 · 4 months · monthly snapshot~Mar 2026 – present · 4 months · monthly snapshot

Change History

70 versions recorded

  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Nov 2025 — Mar 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Oct 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Jul 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 65 earlier versions

  1. Jun 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE2

  2. May 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Apr 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Jan 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Dec 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE2

  6. Nov 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE2

  7. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE2

  8. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE2

  9. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  10. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

  11. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  12. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE2

  13. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE2

  14. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE2

  15. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE2

  16. Jan 2024 — Feb 2024 [monthly]

    Active Not Recruiting PHASE2

  17. Dec 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  18. Oct 2023 — Dec 2023 [monthly]

    Recruiting PHASE2

  19. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE2

  20. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE2

  21. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE2

  22. May 2023 — Jul 2023 [monthly]

    Recruiting PHASE2

  23. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE2

  24. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

  25. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE2

  26. Nov 2022 — Feb 2023 [monthly]

    Recruiting PHASE2

  27. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE2

  28. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  29. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  30. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  31. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE2

  32. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE2

  33. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE2

  34. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE2

  35. Nov 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  36. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  37. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  38. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  39. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE2

    Status: Active Not Recruiting → Recruiting

  40. Mar 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  41. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  42. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  43. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  44. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  45. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE2

  46. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE2

  47. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  48. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  49. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  50. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

  51. Mar 2020 — May 2020 [monthly]

    Recruiting PHASE2

  52. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  53. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2

  54. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  55. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  56. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  57. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  58. Aug 2019 — Sep 2019 [monthly]

    Not Yet Recruiting PHASE2

  59. Jul 2019 — Aug 2019 [monthly]

    Not Yet Recruiting PHASE2

  60. Jun 2019 — Jul 2019 [monthly]

    Not Yet Recruiting PHASE2

  61. May 2019 — Jun 2019 [monthly]

    Not Yet Recruiting PHASE2

  62. Apr 2019 — May 2019 [monthly]

    Not Yet Recruiting PHASE2

  63. Mar 2019 — Apr 2019 [monthly]

    Not Yet Recruiting PHASE2

  64. Feb 2019 — Mar 2019 [monthly]

    Not Yet Recruiting PHASE2

  65. Jan 2019 — Feb 2019 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations