deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT03810911

Mechanisms of EPO-induced Hypertension (EPIC)

Mechanisms of Erythropoietin Induced Hypertension

Sponsor: VA Office of Research and Development

Conditions Anemia Blood Pressure Chronic Kidney Disease
Interventions Darbepoetin
Updated 18 times since 2019 Last updated: Nov 26, 2025 Started: Jan 4, 2021 Primary completion: Dec 31, 2024 Completion: Jul 31, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

The trial was stopped because of inability to reach target sample size.

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Listed as NCT03810911, this PHASE2 trial focuses on Anemia and Blood Pressure and remains terminated or withdrawn. Sponsored by VA Office of Research and Development, it has been updated 18 times since 2021, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Jun 2019 · 3 months · monthly snapshot~Jun 2019 – ~Aug 2019 · 2 months · monthly snapshot~Aug 2019 – ~Oct 2019 · 2 months · monthly snapshot~Oct 2019 – ~Feb 2020 · 4 months · monthly snapshot~Feb 2020 – ~May 2020 · 3 months · monthly snapshot~May 2020 – ~Nov 2020 · 6 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Mar 2022 · 12 months · monthly snapshot~Mar 2022 – ~Feb 2023 · 11 months · monthly snapshot~Feb 2023 – ~Apr 2024 · 14 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~Oct 2025 · 7 months · monthly snapshot~Oct 2025 – ~Jan 2026 · 3 months · monthly snapshot~Jan 2026 – present · 8 months · monthly snapshot

Change History

18 versions recorded

  1. Jan 2026 — Present [monthly]

    Terminated PHASE2

    Status: Completed → Terminated

  2. Oct 2025 — Jan 2026 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  3. Mar 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Sep 2024 — Mar 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

▶ Show 13 earlier versions

  1. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  2. Feb 2023 — Apr 2024 [monthly]

    Recruiting PHASE2

  3. Mar 2022 — Feb 2023 [monthly]

    Recruiting PHASE2

  4. Mar 2021 — Mar 2022 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  5. Jan 2021 — Mar 2021 [monthly]

    Not Yet Recruiting PHASE2

  6. Nov 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE2

  7. May 2020 — Nov 2020 [monthly]

    Not Yet Recruiting PHASE2

  8. Feb 2020 — May 2020 [monthly]

    Not Yet Recruiting PHASE2

  9. Oct 2019 — Feb 2020 [monthly]

    Not Yet Recruiting PHASE2

  10. Aug 2019 — Oct 2019 [monthly]

    Not Yet Recruiting PHASE2

  11. Jun 2019 — Aug 2019 [monthly]

    Not Yet Recruiting PHASE2

  12. Mar 2019 — Jun 2019 [monthly]

    Not Yet Recruiting PHASE2

  13. Feb 2019 — Mar 2019 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • VA Office of Research and Development
Data source: VA Office of Research and Development

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations