deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 8-arm NCT03861234

A Study to Test Different Doses of BI 836880 in Patients With an Eye Disease Called Wet Age-related Macular Degeneration (wAMD)

Safety, Tolerability and Pharmacodynamics of Single Rising Intravitreal and Multiple Rising Intravitreal Doses of BI 836880 in Patients With wAMD (Open Label, Non-randomized, Uncontrolled).

Sponsor: Boehringer Ingelheim

Conditions Wet Macular Degeneration
Interventions BI 836880
Updated 57 times since 2019 Last updated: Oct 29, 2024 Started: Jun 27, 2019 Primary completion: Nov 1, 2023 Completion: Nov 1, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1/PHASE2 trial investigates Wet Macular Degeneration and is currently completed. Boehringer Ingelheim leads this study, which shows 57 recorded versions since 2019 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Apr 2022 · 59 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Nov 2023 · 2 months · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – present · 20 months · monthly snapshot

Change History

57 versions recorded

  1. Dec 2024 — Present [monthly]

    Completed PHASE1/PHASE2

  2. Sep 2024 — Dec 2024 [monthly]

    Completed PHASE1/PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  4. Mar 2024 — Jul 2024 [monthly]

    Completed PHASE1_PHASE2

  5. Feb 2024 — Mar 2024 [monthly]

    Completed PHASE1_PHASE2

▶ Show 52 earlier versions

  1. Jan 2024 — Feb 2024 [monthly]

    Completed PHASE1_PHASE2

  2. Dec 2023 — Jan 2024 [monthly]

    Completed PHASE1_PHASE2

    Status: Active Not Recruiting → Completed

  3. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  4. Sep 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  5. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  6. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE1_PHASE2

  7. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE1_PHASE2

  8. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE1_PHASE2

  9. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE1_PHASE2

  10. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE1_PHASE2

  11. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE1_PHASE2

  12. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE1_PHASE2

  13. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE1_PHASE2

  14. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE1_PHASE2

    Status: Suspended → Recruiting

  15. Sep 2022 — Nov 2022 [monthly]

    Suspended PHASE1_PHASE2

  16. Jul 2022 — Sep 2022 [monthly]

    Suspended PHASE1_PHASE2

  17. Jun 2022 — Jul 2022 [monthly]

    Suspended PHASE1_PHASE2

  18. May 2022 — Jun 2022 [monthly]

    Suspended PHASE1_PHASE2

  19. Apr 2022 — May 2022 [monthly]

    Suspended PHASE1_PHASE2

    Status: Recruiting → Suspended

  20. Feb 2022 — Apr 2022 [monthly]

    Recruiting PHASE1_PHASE2

  21. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE1_PHASE2

  22. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE1_PHASE2

  23. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE1_PHASE2

  24. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE1_PHASE2

  25. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1_PHASE2

    Phase: PHASE1 → PHASE1_PHASE2

  26. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  27. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE1

  28. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE1

  29. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE1

  30. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  31. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

  32. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  33. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  34. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1

  35. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  36. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  37. Jul 2020 — Aug 2020 [monthly]

    Suspended PHASE1

  38. Jun 2020 — Jul 2020 [monthly]

    Suspended PHASE1

  39. May 2020 — Jun 2020 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  40. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1

  41. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  42. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  43. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  44. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  45. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  46. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  47. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  48. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  49. Jul 2019 — Aug 2019 [monthly]

    Not Yet Recruiting PHASE1

  50. Jun 2019 — Jul 2019 [monthly]

    Not Yet Recruiting PHASE1

  51. May 2019 — Jun 2019 [monthly]

    Not Yet Recruiting PHASE1

  52. Apr 2019 — May 2019 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Boehringer Ingelheim
Data source: Boehringer Ingelheim

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Abilene, United States , Austin, United States , Bellaire, United States , Berlin, Germany , Bristol, United Kingdom , Erie, United States , Eugene, United States , Göttingen, Germany , Liverpool, United Kingdom , London, United Kingdom and 4 more locations