deltatrials
Completed PHASE1 INTERVENTIONAL 11-arm NCT03468426

A Study to Test Different Doses of BI 836880 Combined With Ezabenlimab in Patients With Advanced Non-small Cell Lung Cancer Followed by Other Types of Advanced Solid Tumours

An Open Label Phase Ib Dose Finding Study of BI 836880 in Combination With Ezabenlimab to Characterize Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy in Patients With Locally Advanced or Metastatic Non-squamous Non-Small Cell Lung Cancer and in Other Solid Tumors

Sponsor: Boehringer Ingelheim

Conditions Neoplasms Non-squamous, Non-Small-Cell Lung Cancer
Interventions BI 836880 Ezabenlimab
Updated 73 times since 2018 Last updated: Oct 23, 2025 Started: Jul 5, 2018 Primary completion: Jul 31, 2024 Completion: Sep 12, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Neoplasms and Non-squamous, Non-Small-Cell Lung Cancer and is currently completed. Boehringer Ingelheim leads this study, which shows 73 recorded versions since 2018 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Dec 2023 · 2 months · monthly snapshot~Dec 2023 – ~Apr 2024 · 4 months · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Sep 2025 · 8 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – present · 8 months · monthly snapshot

Change History

73 versions recorded

  1. Dec 2025 — Present [monthly]

    Completed PHASE1

  2. Sep 2025 — Dec 2025 [monthly]

    Completed PHASE1

  3. Jan 2025 — Sep 2025 [monthly]

    Completed PHASE1

  4. Dec 2024 — Jan 2025 [monthly]

    Completed PHASE1

  5. Nov 2024 — Dec 2024 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

▶ Show 68 earlier versions

  1. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  4. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE1

  6. Dec 2023 — Apr 2024 [monthly]

    Active Not Recruiting PHASE1

  7. Oct 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE1

  8. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE1

  9. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE1

  10. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1

  11. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE1

  12. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE1

  13. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE1

  14. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE1

  15. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE1

  16. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting PHASE1

  17. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE1

  18. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE1

  19. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE1

  20. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  21. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE1

  22. May 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE1

  23. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE1

  24. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1

  25. Feb 2022 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  26. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE1

  27. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  28. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE1

  29. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE1

  30. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1

  31. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  32. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE1

  33. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE1

  34. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE1

  35. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  36. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

  37. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  38. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  39. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1

  40. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  41. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

  42. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  43. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  44. May 2020 — Jun 2020 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  45. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1

  46. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  47. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  48. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  49. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  50. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  51. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  52. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  53. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

  54. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE1

  55. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

  56. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  57. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE1

  58. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE1

  59. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE1

  60. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE1

  61. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE1

  62. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE1

  63. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE1

  64. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE1

  65. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE1

  66. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  67. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  68. Apr 2018 — Jun 2018 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Boehringer Ingelheim
Data source: Boehringer Ingelheim

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Atlanta, United States , Augsburg, Germany , Barcelona, Spain , Beverly Hills, United States , Birmingham, United States , Boston, United States , Dijon, France , Dnipropetrovks, Ukraine , Dresden, Germany , Fairfax, United States and 31 more locations