deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT03914326

A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes (SOUL)

Semaglutide Cardiovascular Outcomes Trial in Patients With Type 2 Diabetes

Sponsor: Novo Nordisk A/S

Conditions Diabetes Mellitus, Type 2
Interventions Placebo (semaglutide) Semaglutide
Updated 64 times since 2019 Last updated: Nov 24, 2025 Started: Jun 17, 2019 Primary completion: Aug 23, 2024 Completion: Aug 23, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Diabetes Mellitus, Type 2, this trial is completed. The trial is conducted by Novo Nordisk A/S and has accumulated 64 data snapshots since 2019. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Dec 2021 · 2 months · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Apr 2022 · 59 days · monthly snapshot~Apr 2022 – ~Dec 2022 · 8 months · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Feb 2024 · 2 months · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Feb 2025 · 2 months · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Sep 2025 · 4 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – ~Jan 2026 · 2 months · monthly snapshot~Jan 2026 – present · 5 months · monthly snapshot

Change History

64 versions recorded

  1. Jan 2026 — Present [monthly]

    Completed PHASE3

  2. Nov 2025 — Jan 2026 [monthly]

    Completed PHASE3

  3. Oct 2025 — Nov 2025 [monthly]

    Completed PHASE3

  4. Sep 2025 — Oct 2025 [monthly]

    Completed PHASE3

  5. May 2025 — Sep 2025 [monthly]

    Completed PHASE3

▶ Show 59 earlier versions

  1. Apr 2025 — May 2025 [monthly]

    Completed PHASE3

  2. Mar 2025 — Apr 2025 [monthly]

    Completed PHASE3

  3. Feb 2025 — Mar 2025 [monthly]

    Completed PHASE3

  4. Dec 2024 — Feb 2025 [monthly]

    Completed PHASE3

  5. Nov 2024 — Dec 2024 [monthly]

    Completed PHASE3

  6. Oct 2024 — Nov 2024 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  7. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE3

  8. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  9. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE3

  10. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  11. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE3

  12. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE3

  13. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE3

  14. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE3

  15. Dec 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE3

  16. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE3

  17. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

  18. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE3

  19. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE3

  20. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE3

  21. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE3

  22. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE3

  23. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  24. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE3

  25. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE3

  26. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting PHASE3

  27. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE3

  28. Apr 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE3

  29. Feb 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE3

  30. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting PHASE3

  31. Dec 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE3

  32. Oct 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  33. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE3

  34. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  35. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE3

  36. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE3

  37. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE3

  38. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  39. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  40. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  41. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE3

  42. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE3

  43. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE3

  44. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE3

  45. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE3

  46. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE3

  47. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE3

  48. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE3

  49. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE3

  50. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE3

  51. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE3

  52. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE3

  53. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE3

  54. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE3

  55. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  56. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE3

  57. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  58. Jun 2019 — Jul 2019 [monthly]

    Not Yet Recruiting PHASE3

  59. May 2019 — Jun 2019 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Novo Nordisk A/S
Data source: Novo Nordisk A/S

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

A Coruña, Spain , Aarhus N, Denmark , Aberdeen, United Kingdom , Adana, Turkey (Türkiye) , Addlestone, United Kingdom , Aguascalientes, Mexico , Ahmedabad, India , Albany, United States , Alcorcón, Spain , Algiers, Algeria and 355 more locations