deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 1-arm NCT03919071

Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma

A Phase 2 Study of Dabrafenib (NSC# 763760) With Trametinib (NSC# 763093) After Local Irradiation in Newly-Diagnosed BRAF V600-Mutant High-Grade Glioma (HGG)

Sponsor: National Cancer Institute (NCI)

Conditions Anaplastic Astrocytoma Anaplastic Astrocytoma, Not Otherwise Specified Anaplastic Ganglioglioma Anaplastic Pleomorphic Xanthoastrocytoma Glioblastoma Malignant Glioma WHO Grade 3 Glioma WHO Grade 4 Glioma
Interventions Biospecimen Collection Dabrafenib Mesylate Lumbar Puncture Magnetic Resonance Imaging Radiation Therapy Trametinib Dimethyl Sulfoxide
Updated 68 times since 2019 Last updated: Mar 12, 2026 Started: Feb 20, 2020 Primary completion: Sep 30, 2027 Completion: Sep 30, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Anaplastic Astrocytoma and Anaplastic Astrocytoma, Not Otherwise Specified and is currently ongoing. National Cancer Institute (NCI) leads this study, which shows 68 recorded versions since 2020 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~May 2019 – ~Jul 2019 · 2 months · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Nov 2019 · 3 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Mar 2022 · 59 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Jan 2024 · 2 months · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Jun 2025 · 3 months · monthly snapshot~Jun 2025 – ~Aug 2025 · 2 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Dec 2025 · 2 months · monthly snapshot~Dec 2025 – ~Feb 2026 · 2 months · monthly snapshot~Feb 2026 – ~Mar 2026 · 28 days · monthly snapshot~Mar 2026 – present · 6 months · monthly snapshot

Change History

68 versions recorded

  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Feb 2026 — Mar 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Dec 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2

  4. Oct 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 63 earlier versions

  1. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

  2. Jun 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Mar 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  5. Jan 2025 — Feb 2025 [monthly]

    Recruiting PHASE2

  6. Dec 2024 — Jan 2025 [monthly]

    Recruiting PHASE2

  7. Nov 2024 — Dec 2024 [monthly]

    Recruiting PHASE2

  8. Oct 2024 — Nov 2024 [monthly]

    Recruiting PHASE2

  9. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE2

  10. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  11. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE2

  12. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  13. May 2024 — Jun 2024 [monthly]

    Recruiting PHASE2

  14. Apr 2024 — May 2024 [monthly]

    Recruiting PHASE2

  15. Mar 2024 — Apr 2024 [monthly]

    Recruiting PHASE2

  16. Feb 2024 — Mar 2024 [monthly]

    Recruiting PHASE2

  17. Jan 2024 — Feb 2024 [monthly]

    Recruiting PHASE2

  18. Nov 2023 — Jan 2024 [monthly]

    Recruiting PHASE2

  19. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE2

  20. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE2

  21. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE2

  22. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE2

  23. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE2

  24. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE2

  25. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE2

  26. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

  27. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE2

  28. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE2

  29. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE2

  30. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE2

  31. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE2

  32. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  33. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

    Status: Suspended → Recruiting

  34. May 2022 — Jun 2022 [monthly]

    Suspended PHASE2

  35. Apr 2022 — May 2022 [monthly]

    Suspended PHASE2

  36. Mar 2022 — Apr 2022 [monthly]

    Suspended PHASE2

  37. Jan 2022 — Mar 2022 [monthly]

    Suspended PHASE2

  38. Dec 2021 — Jan 2022 [monthly]

    Suspended PHASE2

    Status: Recruiting → Suspended

  39. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  40. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  41. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  42. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  43. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE2

  44. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  45. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  46. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  47. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  48. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  49. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE2

  50. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE2

  51. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  52. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  53. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  54. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

  55. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE2

  56. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  57. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  58. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2

  59. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  60. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  61. Aug 2019 — Nov 2019 [monthly]

    Not Yet Recruiting PHASE2

  62. Jul 2019 — Aug 2019 [monthly]

    Not Yet Recruiting PHASE2

  63. May 2019 — Jul 2019 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Akron, United States , Albany, United States , Albuquerque, United States , Allentown, United States , Ann Arbor, United States , Asheville, United States , Atlanta, United States , Aurora, United States , Austin, United States , Baltimore, United States and 99 more locations