deltatrials
Completed PHASE1 INTERVENTIONAL 4-arm NCT03964233

A Study in Patients With Different Types of Advanced Cancer (Solid Tumors) to Test Different Doses of BI 907828 (Brigimadlin) in Combination With BI 754091 (Ezabenlimab) and BI 754111 or BI 907828 (Brigimadlin) in Combination With BI 754091 (Ezabenlimab)

A Phase Ia/Ib, Open Label, Dose-escalation Study of the Combination of BI 907828 (Brigimadlin) With BI 754091 (Ezabenlimab) and BI 754111 and the Combination of BI 907828 (Brigimadlin) With BI 754091(Ezabenlimab) Followed by Expansion Cohorts, in Patients With Advanced Solid Tumors

Sponsor: Boehringer Ingelheim

Conditions Neoplasms
Interventions BI 754111 BI 907828 ezabenlimab
Updated 64 times since 2019 Last updated: Feb 17, 2026 Started: Jun 20, 2019 Primary completion: Sep 5, 2024 Completion: Feb 6, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Neoplasms and is currently completed. Boehringer Ingelheim leads this study, which shows 64 recorded versions since 2019 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Nov 2023 · 3 months · monthly snapshot~Nov 2023 – ~Apr 2024 · 5 months · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Feb 2025 · 2 months · monthly snapshot~Feb 2025 – ~May 2025 · 3 months · monthly snapshot~May 2025 – ~Jul 2025 · 2 months · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Feb 2026 · 4 months · monthly snapshot~Feb 2026 – present · 7 months · monthly snapshot

Change History

64 versions recorded

  1. Feb 2026 — Present [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  2. Oct 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE1

  3. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Jul 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE1

▶ Show 59 earlier versions

  1. May 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE1

  2. Feb 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Dec 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Nov 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE1

  6. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE1

  7. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  8. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE1

  9. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  10. May 2024 — Jun 2024 [monthly]

    Recruiting PHASE1

  11. Apr 2024 — May 2024 [monthly]

    Recruiting PHASE1

  12. Nov 2023 — Apr 2024 [monthly]

    Recruiting PHASE1

  13. Aug 2023 — Nov 2023 [monthly]

    Recruiting PHASE1

  14. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE1

  15. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE1

  16. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE1

  17. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE1

  18. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE1

  19. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE1

  20. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE1

  21. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE1

  22. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  23. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE1

  24. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  25. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE1

  26. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

  27. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1

  28. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE1

  29. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE1

  30. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE1

  31. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  32. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE1

  33. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE1

  34. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1

  35. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  36. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE1

  37. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE1

  38. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE1

  39. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  40. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

  41. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  42. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  43. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1

  44. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  45. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

  46. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  47. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  48. May 2020 — Jun 2020 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  49. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1

  50. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  51. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  52. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  53. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  54. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  55. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  56. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  57. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  58. Jul 2019 — Aug 2019 [monthly]

    Not Yet Recruiting PHASE1

  59. Jun 2019 — Jul 2019 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Boehringer Ingelheim
Data source: Boehringer Ingelheim

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Athens, United States , Barcelona, Spain , Bordeaux, France , Budapest, Hungary , Fairfax, United States , Frankfurt, Germany , Groningen, Netherlands , Houston, United States , Irving, United States , Leuven, Belgium and 13 more locations