deltatrials
Completed PHASE1 INTERVENTIONAL 11-arm NCT03156114

This Study Tests the New Medicine BI 754111 Alone or in Combination With Another New Substance BI 754091 in Patients With Advanced Cancer. The Study Tests Different Doses to Find the Best Dose for Continuous Treatment.

An Open Label, Phase I Dose-finding Study of BI 754111 in Combination With BI 754091 in Patients With Advanced Solid Cancers Followed by Expansion Cohorts at the Selected Dose of the Combination in Patients With Non-small Cell Lung Cancer and Other Solid Tumors

Sponsor: Boehringer Ingelheim

Conditions Carcinoma, Non-Small-Cell Lung Neoplasms
Interventions BI 754111 Ezabenlimab
Updated 68 times since 2017 Last updated: Jan 7, 2026 Started: Jun 13, 2017 Primary completion: Mar 9, 2023 Completion: Jun 6, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Carcinoma, Non-Small-Cell Lung and Neoplasms and is currently completed. Boehringer Ingelheim leads this study, which shows 68 recorded versions since 2017 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jun 2017 – ~Jul 2017 · 30 days · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Nov 2017 · 3 months · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Mar 2018 · 3 months · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Jul 2024 · 12 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – ~Feb 2026 · 5 months · monthly snapshot~Feb 2026 – present · 6 months · monthly snapshot

Change History

68 versions recorded

  1. Feb 2026 — Present [monthly]

    Completed PHASE1

  2. Sep 2025 — Feb 2026 [monthly]

    Completed PHASE1

  3. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE1

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  5. Jul 2023 — Jul 2024 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

▶ Show 63 earlier versions

  1. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE1

  2. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE1

  3. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE1

  4. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE1

  5. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE1

  6. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting PHASE1

  7. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE1

  8. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE1

  9. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE1

  10. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  11. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE1

  12. May 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE1

  13. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE1

  14. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1

  15. Feb 2022 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1

  16. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting PHASE1

  17. Dec 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE1

  18. Nov 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE1

  19. Oct 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE1

  20. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE1

  21. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1

  22. May 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE1

  23. Apr 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE1

  24. Mar 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE1

  25. Feb 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE1

  26. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE1

  27. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

  28. Nov 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  29. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1

  30. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  31. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

  32. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  33. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  34. May 2020 — Jun 2020 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  35. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1

  36. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  37. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  38. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  39. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  40. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  41. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  42. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  43. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

  44. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE1

  45. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

  46. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  47. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE1

  48. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE1

  49. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE1

  50. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE1

  51. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE1

  52. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE1

  53. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE1

  54. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE1

  55. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE1

  56. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  57. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1

  58. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE1

  59. Dec 2017 — Mar 2018 [monthly]

    Recruiting PHASE1

  60. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE1

  61. Aug 2017 — Nov 2017 [monthly]

    Recruiting PHASE1

  62. Jul 2017 — Aug 2017 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  63. Jun 2017 — Jul 2017 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Boehringer Ingelheim
Data source: Boehringer Ingelheim

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Barcelona, Spain , Edmonton, Canada , Hackensack, United States , Józefów, Poland , London, United Kingdom , Madrid, Spain , Miami, United States , Milwaukee, United States , Nashville, United States , Oklahoma City, United States and 4 more locations