deltatrials
Active Not Recruiting NA INTERVENTIONAL 1-arm NCT03978663

Three Fraction Radiation to Induce Immuno-Oncologic Response (TRIO)

Evaluating the Use of Stereotactic Radiation Therapy Prior to Neoadjuvant Chemotherapy for High-risk Breast Carcinoma (a SIGNAL Series Clinical Trial): Three Fraction Radiation to Induce Immuno-Oncologic Response (TRIO Trial)

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Updated 13 times since 2019 Last updated: Feb 18, 2026 Started: Sep 2, 2020 Primary completion: Jul 31, 2026 Completion: Jul 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This NA trial investigates High-Risk Cancer and Locally Advanced Breast Cancer and is currently ongoing. London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's leads this study, which shows 13 recorded versions since 2020 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jul 2019 – ~Jul 2020 · 12 months · monthly snapshot~Jul 2020 – ~Sep 2020 · 2 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~May 2023 · 20 months · monthly snapshot~May 2023 – ~Feb 2024 · 9 months · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Mar 2025 · 59 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~Feb 2026 · 10 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

13 versions recorded
  1. Feb 2026 — Present [monthly]

    Active Not Recruiting NA

  2. Apr 2025 — Feb 2026 [monthly]

    Active Not Recruiting NA

  3. Mar 2025 — Apr 2025 [monthly]

    Active Not Recruiting NA

    Status: RecruitingActive Not Recruiting

  4. Jan 2025 — Mar 2025 [monthly]

    Recruiting NA

  5. Sep 2024 — Jan 2025 [monthly]

    Recruiting NA

Show 8 earlier versions
  1. Jul 2024 — Sep 2024 [monthly]

    Recruiting NA

  2. Feb 2024 — Jul 2024 [monthly]

    Recruiting NA

  3. May 2023 — Feb 2024 [monthly]

    Recruiting NA

  4. Sep 2021 — May 2023 [monthly]

    Recruiting NA

  5. Jan 2021 — Sep 2021 [monthly]

    Recruiting NA

  6. Sep 2020 — Jan 2021 [monthly]

    Recruiting NA

    Status: Not Yet RecruitingRecruiting

  7. Jul 2020 — Sep 2020 [monthly]

    Not Yet Recruiting NA

  8. Jul 2019 — Jul 2020 [monthly]

    Not Yet Recruiting NA

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Data source: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations