A Study to Investigate the Efficacy of Zanubrutinib Plus Rituximab Compared With Bendamustine Plus Rituximab in Adults With Previously Untreated Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation (MANGROVE)
A Phase 3 Randomized, Open-Label, Multicenter Study Comparing Zanubrutinib (BGB-3111) Plus Rituximab Versus Bendamustine Plus Rituximab in Patients With Previously Untreated Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation
Sponsor: BeiGene
This PHASE3 trial investigates Mantle Cell Lymphoma; Non-Hodgkin Lymphoma and is currently ongoing. BeiGene leads this study, which shows 32 recorded versions since 2019 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.
Status Flow
Change History
32 versions recorded-
Dec 2025 — Present [monthly]
Active Not Recruiting PHASE3
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Oct 2025 — Dec 2025 [monthly]
Active Not Recruiting PHASE3
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Sep 2025 — Oct 2025 [monthly]
Active Not Recruiting PHASE3
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Mar 2025 — Sep 2025 [monthly]
Active Not Recruiting PHASE3
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Jan 2025 — Mar 2025 [monthly]
Active Not Recruiting PHASE3
▶ Show 27 earlier versions
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Nov 2024 — Jan 2025 [monthly]
Active Not Recruiting PHASE3
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Sep 2024 — Nov 2024 [monthly]
Active Not Recruiting PHASE3
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Jul 2024 — Sep 2024 [monthly]
Active Not Recruiting PHASE3
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Feb 2024 — Jul 2024 [monthly]
Active Not Recruiting PHASE3
Status: Recruiting → Active Not Recruiting
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Sep 2023 — Feb 2024 [monthly]
Recruiting PHASE3
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Aug 2023 — Sep 2023 [monthly]
Recruiting PHASE3
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Sep 2022 — Aug 2023 [monthly]
Recruiting PHASE3
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May 2022 — Sep 2022 [monthly]
Recruiting PHASE3
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Apr 2022 — May 2022 [monthly]
Recruiting PHASE3
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Jan 2022 — Apr 2022 [monthly]
Recruiting PHASE3
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Dec 2021 — Jan 2022 [monthly]
Recruiting PHASE3
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Nov 2021 — Dec 2021 [monthly]
Recruiting PHASE3
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Oct 2021 — Nov 2021 [monthly]
Recruiting PHASE3
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Sep 2021 — Oct 2021 [monthly]
Recruiting PHASE3
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Jun 2021 — Sep 2021 [monthly]
Recruiting PHASE3
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May 2021 — Jun 2021 [monthly]
Recruiting PHASE3
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Jan 2021 — May 2021 [monthly]
Recruiting PHASE3
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Nov 2020 — Jan 2021 [monthly]
Recruiting PHASE3
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Oct 2020 — Nov 2020 [monthly]
Recruiting PHASE3
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Aug 2020 — Oct 2020 [monthly]
Recruiting PHASE3
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Jul 2020 — Aug 2020 [monthly]
Recruiting PHASE3
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Jun 2020 — Jul 2020 [monthly]
Recruiting PHASE3
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May 2020 — Jun 2020 [monthly]
Recruiting PHASE3
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Mar 2020 — May 2020 [monthly]
Recruiting PHASE3
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Nov 2019 — Mar 2020 [monthly]
Recruiting PHASE3
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Oct 2019 — Nov 2019 [monthly]
Recruiting PHASE3
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Jul 2019 — Oct 2019 [monthly]
Recruiting PHASE3
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- BeiGene
For direct contact, visit the study record on ClinicalTrials.gov .