deltatrials
Completed PHASE1 INTERVENTIONAL 8-arm NCT04018664

Oral Abuse Potential Study of Nalbuphine

A Study to Evaluate the Oral Abuse Potential of Nalbuphine Solution and Extended-Release Intact Tablets in Non-Dependent, Recreational Opioid Users

Sponsor: Syneos Health

Updated 11 times since 2019 Last updated: May 19, 2025 Started: May 29, 2018 Primary completion: Dec 3, 2018 Completion: Jun 2, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04018664, this PHASE1 trial focuses on Nalbuphine and Opioid Abuse and remains completed. Sponsored by Syneos Health, it has been updated 11 times since 2018, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshotSuspended~Sep 2019 – ~Feb 2020 · 5 months · monthly snapshotSuspended~Feb 2020 – ~Jul 2020 · 5 months · monthly snapshotSuspended~Jul 2020 – ~Sep 2020 · 2 months · monthly snapshotCompleted~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshotCompleted~Jan 2021 – ~Dec 2022 · 23 months · monthly snapshotCompleted~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshotCompleted~Jan 2023 – ~Jul 2024 · 18 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – ~Jun 2025 · 9 months · monthly snapshotCompleted~Jun 2025 – present · 13 months · monthly snapshotCompleted

Change History

11 versions recorded
  1. Jun 2025 — Present [monthly]

    Completed PHASE1

  2. Sep 2024 — Jun 2025 [monthly]

    Completed PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  4. Jan 2023 — Jul 2024 [monthly]

    Completed PHASE1

  5. Dec 2022 — Jan 2023 [monthly]

    Completed PHASE1

Show 6 earlier versions
  1. Jan 2021 — Dec 2022 [monthly]

    Completed PHASE1

  2. Sep 2020 — Jan 2021 [monthly]

    Completed PHASE1

  3. Jul 2020 — Sep 2020 [monthly]

    Completed PHASE1

    Status: SuspendedCompleted

  4. Feb 2020 — Jul 2020 [monthly]

    Suspended PHASE1

  5. Sep 2019 — Feb 2020 [monthly]

    Suspended PHASE1

  6. Aug 2019 — Sep 2019 [monthly]

    Suspended PHASE1

    First recorded

May 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Syneos Health
  • Trevi Therapeutics
Data source: Trevi Therapeutics

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations