Completed PHASE3 INTERVENTIONAL 3-arm NCT04028492

Evaluating the Safety and Efficacy of Tradipitant vs. Placebo in Idiopathic and Diabetic Gastroparesis

VP-VLY-686-3301: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase Iii Study To Assess The Efficacy Of Tradipitant In Relieving Symptoms Of Gastroparesis

Sponsor: Vanda Pharmaceuticals

Conditions Diabetic Gastroparesis Gastroparesis Idiopathic Gastroparesis

Interventions Open Label Tradipitant Placebo Tradipitant

Updated 9 times since 2019 Last updated: Jul 21, 2025 Started: Aug 20, 2019 Primary completion: Feb 21, 2025 Completion: Feb 21, 2025

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04028492, this PHASE3 trial focuses on Diabetic Gastroparesis and Gastroparesis and remains completed. Sponsored by Vanda Pharmaceuticals, it has been updated 9 times since 2019, reflecting limited change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

Change History

9 versions recorded

Aug 2025 — Present [monthly]

Completed PHASE3

Status: Recruiting → Completed
Sep 2024 — Aug 2025 [monthly]

Recruiting PHASE3
Jul 2024 — Sep 2024 [monthly]

Recruiting PHASE3
Apr 2024 — Jul 2024 [monthly]

Recruiting PHASE3
Oct 2023 — Apr 2024 [monthly]

Recruiting PHASE3

Status: Unknown Status → Recruiting

▶ Show 4 earlier versions

Apr 2023 — Oct 2023 [monthly]

Unknown Status PHASE3

Status: Recruiting → Unknown Status
Apr 2021 — Apr 2023 [monthly]

Recruiting PHASE3
Jan 2021 — Apr 2021 [monthly]

Recruiting PHASE3
Aug 2019 — Jan 2021 [monthly]

Recruiting PHASE3

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Vanda Pharmaceuticals

Data source: Vanda Pharmaceuticals

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Birmingham, United States , Boston, United States , Brooklyn, United States , Charlotte, United States , Chattanooga, United States , Chesterfield, United States , Chevy Chase, United States , Chula Vista, United States , Columbus, United States , Edmond, United States and 23 more locations