deltatrials
Terminated PHASE1 INTERVENTIONAL 2-arm NCT04070781

Itacitinib and Tocilizumab for Steroid Refractory Acute Graft Versus Host Disease (GVHD)

Phase I Study of Itacitinib in Combination With Tocilizumab for the Treatment of Steroid Refractory Acute Graft Versus Host Disease

Sponsor: Columbia University

Updated 8 times since 2019 Last updated: May 31, 2024 Started: Jan 20, 2020 Primary completion: Dec 13, 2021 Completion: Dec 13, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

The primary reason for study closure is slow enrollment.

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This PHASE1 trial investigates Graft Vs Host Disease and Steroid Refractory GVHD and is currently terminated or withdrawn. Columbia University leads this study, which shows 8 recorded versions since 2020 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Sep 2019 – ~Feb 2020 · 5 months · monthly snapshotNot Yet Recruiting~Feb 2020 – ~Jan 2021 · 11 months · monthly snapshotNot Yet Recruiting~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshotNot Yet Recruiting~Feb 2021 – ~Jun 2022 · 16 months · monthly snapshotRecruiting~Jun 2022 – ~Jun 2023 · 12 months · monthly snapshotRecruiting~Jun 2023 – ~Jul 2024 · 13 months · monthly snapshotTerminated~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotTerminated~Sep 2024 – present · 22 months · monthly snapshotTerminated

Change History

8 versions recorded
  1. Sep 2024 — Present [monthly]

    Terminated PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1

  3. Jun 2023 — Jul 2024 [monthly]

    Terminated PHASE1

    Status: RecruitingTerminated

  4. Jun 2022 — Jun 2023 [monthly]

    Recruiting PHASE1

  5. Feb 2021 — Jun 2022 [monthly]

    Recruiting PHASE1

    Status: Not Yet RecruitingRecruiting

Show 3 earlier versions
  1. Jan 2021 — Feb 2021 [monthly]

    Not Yet Recruiting PHASE1

  2. Feb 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE1

  3. Sep 2019 — Feb 2020 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Columbia University
  • Incyte Corporation
Data source: Columbia University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations