Lorlatinib After Failure of First-line Second-generation ALK Kinase Inhibitor in Patients With Advanced ALK-positive Non-small Cell Lung Cancer (ORAKLE)
A Phase II Non-randomized, Single Group Assignment, Open-label, Multicenter Study of Efficacy and Safety of Lorlatinib Monotherapy After Failure of First-line Second-generation ALK Kinase Inhibitor in Patients With Advanced ALK-positive Non-small Cell Lung Cancer
Sponsor: Intergroupe Francophone de Cancerologie Thoracique
A PHASE2 clinical study on Non Small Cell Lung Cancer Metastatic, this trial is completed. The trial is conducted by Intergroupe Francophone de Cancerologie Thoracique and has accumulated 14 data snapshots since 2020. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.
Status Flow
Change History
14 versions recorded-
Sep 2025 — Present [monthly]
Completed PHASE2
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May 2025 — Sep 2025 [monthly]
Completed PHASE2
Status: Active Not Recruiting → Completed
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Nov 2024 — May 2025 [monthly]
Active Not Recruiting PHASE2
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Sep 2024 — Nov 2024 [monthly]
Active Not Recruiting PHASE2
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Jul 2024 — Sep 2024 [monthly]
Active Not Recruiting PHASE2
▶ Show 9 earlier versions
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Apr 2024 — Jul 2024 [monthly]
Active Not Recruiting PHASE2
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Oct 2023 — Apr 2024 [monthly]
Active Not Recruiting PHASE2
Status: Recruiting → Active Not Recruiting
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May 2022 — Oct 2023 [monthly]
Recruiting PHASE2
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Jan 2021 — May 2022 [monthly]
Recruiting PHASE2
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Oct 2020 — Jan 2021 [monthly]
Recruiting PHASE2
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Aug 2020 — Oct 2020 [monthly]
Recruiting PHASE2
-
May 2020 — Aug 2020 [monthly]
Recruiting PHASE2
Status: Not Yet Recruiting → Recruiting
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Mar 2020 — May 2020 [monthly]
Not Yet Recruiting PHASE2
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Nov 2019 — Mar 2020 [monthly]
Not Yet Recruiting PHASE2
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- Intergroupe Francophone de Cancerologie Thoracique
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
Angers, France , Annecy, France , Bayonne, France , Besançon, France , Bordeaux, France , Boulogne-Billancourt, France , Caen, France , Colmar, France , Créteil, France , Dijon, France and 17 more locations