deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT04113863

Evaluation of ATRA Activity in Combination With Anastrozole in Pre-operative Phase of Operable Early Breast Cancer (ATRA)

A Randomized Phase 2 Clinical Trial to Evaluate the Activity of ATRA in Combination With Anastrozole in Pre-operative Phase of Operable HR-positive/HER2-negative Early Breast Cancer (ATRA)

Sponsor: Mario Negri Institute for Pharmacological Research

Updated 9 times since 2019 Last updated: Dec 10, 2025 Started: Jun 18, 2019 Primary completion: Jan 30, 2025 Completion: Jan 30, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Low enrolment rate

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Listed as NCT04113863, this PHASE2 trial focuses on Breast Neoplasm Female and remains terminated or withdrawn. Sponsored by Mario Negri Institute for Pharmacological Research, it has been updated 9 times since 2019, reflecting limited change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Nov 2019 – ~Jan 2021 · 14 months · monthly snapshotRecruiting~Jan 2021 – ~Nov 2021 · 10 months · monthly snapshotRecruiting~Nov 2021 – ~Apr 2023 · 17 months · monthly snapshotUnknown Status~Apr 2023 – ~Nov 2023 · 7 months · monthly snapshotRecruiting~Nov 2023 – ~Jul 2024 · 8 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Dec 2025 · 15 months · monthly snapshotRecruiting~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshotUnknown~Jan 2026 – present · 6 months · monthly snapshotTerminated

Change History

9 versions recorded
  1. Jan 2026 — Present [monthly]

    Terminated PHASE2

    Status: UnknownTerminated

  2. Dec 2025 — Jan 2026 [monthly]

    Unknown PHASE2

    Status: RecruitingUnknown

  3. Sep 2024 — Dec 2025 [monthly]

    Recruiting PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  5. Nov 2023 — Jul 2024 [monthly]

    Recruiting PHASE2

Show 4 earlier versions
  1. Apr 2023 — Nov 2023 [monthly]

    Recruiting PHASE2

    Status: Unknown StatusRecruiting

  2. Nov 2021 — Apr 2023 [monthly]

    Unknown Status PHASE2

    Status: RecruitingUnknown Status

  3. Jan 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  4. Nov 2019 — Jan 2021 [monthly]

    Recruiting PHASE2

    First recorded

Jun 2019

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Mario Negri Institute for Pharmacological Research
Data source: Mario Negri Institute for Pharmacological Research

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations