deltatrials
Terminated PHASE1 INTERVENTIONAL 1-arm NCT04240704

Safety and Preliminary Efficacy of JBH492 Monotherapy in Patients With CLL and NHL

A Phase I/Ib Open-label, Multi-center Dose Escalation Study of JBH492 in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL) and Non-Hodgkin's Lymphoma (NHL)

Sponsor: Novartis Pharmaceuticals

Conditions Chronic Lymphocytic Leukemia Non-Hodgkins Lymphoma
Interventions JBH492
Updated 27 times since 2020 Last updated: Oct 8, 2025 Started: Sep 7, 2020 Primary completion: Sep 5, 2024 Completion: Sep 5, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Business, strategic, and development considerations and not due to any safety concerns

Other terminated trials from Novartis Pharmaceuticals

See all terminations from Novartis Pharmaceuticals

Other Chronic Lymphocytic Leukemia trials with similar outcome

Browse all Chronic Lymphocytic Leukemia trials

This PHASE1 trial investigates Chronic Lymphocytic Leukemia and Non-Hodgkins Lymphoma and is currently terminated or withdrawn. Novartis Pharmaceuticals leads this study, which shows 27 recorded versions since 2020 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Feb 2020 – ~Jun 2020 · 4 months · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~May 2021 · 2 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Jan 2022 · 4 months · monthly snapshot~Jan 2022 – ~Jul 2022 · 6 months · monthly snapshot~Jul 2022 – ~Dec 2022 · 5 months · monthly snapshot~Dec 2022 – ~Jul 2023 · 7 months · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Nov 2023 · 3 months · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Feb 2024 · 2 months · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Jun 2024 · 3 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Aug 2025 · 9 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – present · 8 months · monthly snapshot

Change History

27 versions recorded

  1. Nov 2025 — Present [monthly]

    Terminated PHASE1

  2. Sep 2025 — Nov 2025 [monthly]

    Terminated PHASE1

  3. Aug 2025 — Sep 2025 [monthly]

    Terminated PHASE1

  4. Nov 2024 — Aug 2025 [monthly]

    Terminated PHASE1

    Status: Active Not Recruiting → Terminated

  5. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE1

▶ Show 22 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  3. Mar 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Dec 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE1

  6. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE1

  7. Aug 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE1

  8. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  9. Dec 2022 — Jul 2023 [monthly]

    Recruiting PHASE1

  10. Jul 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  11. Jan 2022 — Jul 2022 [monthly]

    Recruiting PHASE1

  12. Sep 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  13. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  14. Mar 2021 — May 2021 [monthly]

    Recruiting PHASE1

  15. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  16. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  17. Oct 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  18. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  19. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

  20. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  21. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  22. Feb 2020 — Jun 2020 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Novartis Pharmaceuticals
Data source: Novartis

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations