deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 2-arm NCT04266249

CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

(CompassHER2-pCR): Preoperative THP and Postoperative HP in Patients Who Achieve a Pathologic Complete Response

Sponsor: ECOG-ACRIN Cancer Research Group

Conditions Anatomic Stage II Breast Cancer AJCC v8 Anatomic Stage IIA Breast Cancer AJCC v8 Anatomic Stage IIB Breast Cancer AJCC v8 Anatomic Stage IIIA Breast Cancer AJCC v8 Invasive Breast Carcinoma Prognostic Stage II Breast Cancer AJCC v8 Prognostic Stage IIA Breast Cancer AJCC v8 Prognostic Stage IIB Breast Cancer AJCC v8 Prognostic Stage IIIA Breast Cancer AJCC v8
Interventions Docetaxel Lumpectomy Mastectomy Nab-paclitaxel Paclitaxel Pertuzumab Radiation Therapy Trastuzumab Trastuzumab Emtansine
Updated 27 times since 2020 Last updated: Feb 27, 2026 Started: Mar 13, 2020 Primary completion: Oct 31, 2026 Completion: Dec 31, 2038
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Anatomic Stage II Breast Cancer AJCC v8 and Anatomic Stage IIA Breast Cancer AJCC v8 and is currently ongoing. ECOG-ACRIN Cancer Research Group leads this study, which shows 27 recorded versions since 2020 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Jun 2020 · 2 months · monthly snapshot~Jun 2020 – ~Jan 2021 · 7 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~May 2021 · 2 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Feb 2022 · 2 months · monthly snapshot~Feb 2022 – ~Jun 2022 · 4 months · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Apr 2023 · 7 months · monthly snapshot~Apr 2023 – ~Jun 2023 · 2 months · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~May 2024 · 10 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~May 2025 · 8 months · monthly snapshot~May 2025 – ~Sep 2025 · 4 months · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – ~Mar 2026 · 28 days · monthly snapshot~Mar 2026 – present · 5 months · monthly snapshot

Change History

27 versions recorded

  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Feb 2026 — Mar 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Jan 2026 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2

  4. Dec 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE2

  5. Nov 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 22 earlier versions

  1. Sep 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE2

  2. May 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  3. Sep 2024 — May 2025 [monthly]

    Recruiting PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  5. May 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  6. Jul 2023 — May 2024 [monthly]

    Recruiting PHASE2

  7. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE2

  8. Apr 2023 — Jun 2023 [monthly]

    Recruiting PHASE2

  9. Sep 2022 — Apr 2023 [monthly]

    Recruiting PHASE2

  10. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  11. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  12. Feb 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  13. Dec 2021 — Feb 2022 [monthly]

    Recruiting PHASE2

  14. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  15. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  16. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  17. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  18. Mar 2021 — May 2021 [monthly]

    Recruiting PHASE2

  19. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  20. Jun 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  21. Apr 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  22. Mar 2020 — Apr 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • ECOG-ACRIN Cancer Research Group
  • National Cancer Institute (NCI)
Data source: Eastern Cooperative Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aberdeen, United States , Aitkin, United States , Albemarle, United States , Albuquerque, United States , Alliance, United States , Altamonte Springs, United States , Alton, United States , Altoona, United States , Ames, United States , Anaconda, United States and 631 more locations