Recruiting PHASE2/PHASE3 INTERVENTIONAL 1-arm NCT04353375

HMPL-453 Tartrate in Advanced Intrahepatic Cholangiocarcinoma

An Open-Label, Single-Arm, Multicenter Phase 2/3b Clinical Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of HMPL-453 Tartrate in Patients With Advanced Intrahepatic Cholangiocarcinoma Habouring FGFR2 Fusion/Rearrangement

Sponsor: Hutchmed

Conditions Advanced Intrahepatic Cholangiocarcinoma Solid Tumor, Adult

Interventions HMPL-453

Updated 8 times since 2020 Last updated: Dec 25, 2025 Started: Sep 3, 2020 Primary completion: Jun 30, 2028 Completion: Feb 28, 2030

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2/PHASE3 trial investigates Advanced Intrahepatic Cholangiocarcinoma and Solid Tumor, Adult and is currently actively recruiting participants. Hutchmed leads this study, which shows 8 recorded versions since 2020 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

Change History

8 versions recorded

Jan 2026 — Present [monthly]

Recruiting PHASE2/PHASE3

Phase: PHASE2 → PHASE2/PHASE3
Sep 2024 — Jan 2026 [monthly]

Recruiting PHASE2
Jul 2024 — Sep 2024 [monthly]

Recruiting PHASE2
Aug 2023 — Jul 2024 [monthly]

Recruiting PHASE2

Status: Not Yet Recruiting → Recruiting
Nov 2022 — Aug 2023 [monthly]

Not Yet Recruiting PHASE2

▶ Show 3 earlier versions

Jan 2021 — Nov 2022 [monthly]

Not Yet Recruiting PHASE2
Jul 2020 — Jan 2021 [monthly]

Not Yet Recruiting PHASE2
May 2020 — Jul 2020 [monthly]

Not Yet Recruiting PHASE2

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Hutchmed

Data source: Hutchmed

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Beijing, China