deltatrials
Terminated PHASE1 INTERVENTIONAL 1-arm NCT04764474

A Study of HMPL-306 in Advanced Hematological Malignancies With mIDH

A Phase 1, Open-Label, Multicenter Study of HMPL-306 in Advanced Hematological Malignancies With Isocitrate Dehydrogenase (IDH) Mutations

Sponsor: Hutchmed

Interventions HMPL-306
Updated 11 times since 2021 Last updated: Jan 28, 2026 Started: Apr 12, 2021 Primary completion: Jan 15, 2025 Completion: Jan 15, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

The study was terminated based on strategic evaluation of the clinical development of HMPL-306 with no safety concerns

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This PHASE1 trial investigates Isocitrate Dehydrogenase Gene Mutation and is currently terminated or withdrawn. Hutchmed leads this study, which shows 11 recorded versions since 2021 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Mar 2021 – ~May 2021 · 2 months · monthly snapshot~May 2021 – ~Apr 2022 · 11 months · monthly snapshotRecruiting~Apr 2022 – ~Sep 2022 · 5 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Jun 2023 · 6 months · monthly snapshotRecruiting~Jun 2023 – ~Mar 2024 · 9 months · monthly snapshotRecruiting~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~May 2025 · 8 months · monthly snapshotRecruiting~May 2025 – ~Feb 2026 · 9 months · monthly snapshotTerminated~Feb 2026 – present · 5 months · monthly snapshotTerminated

Change History

11 versions recorded
  1. Feb 2026 — Present [monthly]

    Terminated PHASE1

  2. May 2025 — Feb 2026 [monthly]

    Terminated PHASE1

    Status: RecruitingTerminated

  3. Sep 2024 — May 2025 [monthly]

    Recruiting PHASE1

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  5. Mar 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

Show 6 earlier versions
  1. Jun 2023 — Mar 2024 [monthly]

    Recruiting PHASE1

  2. Dec 2022 — Jun 2023 [monthly]

    Recruiting PHASE1

  3. Sep 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  4. Apr 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  5. May 2021 — Apr 2022 [monthly]

    Recruiting PHASE1

    Status: Not Yet RecruitingRecruiting

  6. Mar 2021 — May 2021 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Hutchmed
Data source: Hutchmed

For direct contact, visit the study record on ClinicalTrials.gov .