deltatrials
Recruiting PHASE2 INTERVENTIONAL 2-arm NCT04388124

Endothelin-1 Receptor Blockade in Resistant Hypertension (ENDOTHELIN-2)

VASCULAR AND RENAL IMPACT OF ENDOTHELIN-1 RECEPTOR BLOCKADE IN PATIENTS WITH RESISTANT ARTERIAL HYPERTENSION

Sponsor: University Hospital, Rouen

Interventions Bosentan Placebo
Updated 6 times since 2020 Last updated: Feb 12, 2026 Started: Oct 20, 2021 Primary completion: Aug 31, 2026 Completion: Aug 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Resistant Hypertension and is currently actively recruiting participants. University Hospital, Rouen leads this study, which shows 6 recorded versions since 2021 — indicating limited longitudinal coverage. Heart and vascular conditions benefit from the kind of long-term tracking this trial provides.

Status Flow

~Jun 2020 – ~Jan 2021 · 7 months · monthly snapshotNot Yet Recruiting~Jan 2021 – ~Dec 2022 · 23 months · monthly snapshotNot Yet Recruiting~Dec 2022 – ~Jul 2024 · 19 months · monthly snapshotUnknown Status~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2026 · 17 months · monthly snapshotUnknown~Feb 2026 – present · 7 months · monthly snapshotRecruiting

Change History

6 versions recorded
  1. Feb 2026 — Present [monthly]

    Recruiting PHASE2

    Status: UnknownRecruiting

  2. Sep 2024 — Feb 2026 [monthly]

    Unknown PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Unknown PHASE2

    Status: Unknown StatusUnknown

  4. Dec 2022 — Jul 2024 [monthly]

    Unknown Status PHASE2

    Status: Not Yet RecruitingUnknown Status

  5. Jan 2021 — Dec 2022 [monthly]

    Not Yet Recruiting PHASE2

Show 1 earlier version
  1. Jun 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • University Hospital, Rouen
Data source: University Hospital, Rouen

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations