deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 4-arm NCT04388839

Evolutionary Therapy for Rhabdomyosarcoma

Evolutionary Inspired Therapy for Newly Diagnosed, Metastatic, Fusion Positive Rhabdomyosarcoma

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Conditions Rhabdomyosarcoma
Interventions Actinomycin D Cyclophosphamide Cyclophosphamide Pill Vincristine Vinorelbine
Updated 30 times since 2020 Last updated: Nov 24, 2025 Started: Dec 29, 2020 Primary completion: Aug 31, 2026 Completion: Aug 31, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Rhabdomyosarcoma, this trial is ongoing. The trial is conducted by H. Lee Moffitt Cancer Center and Research Institute and has accumulated 30 data snapshots since 2020. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~May 2021 · 2 months · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Jan 2022 · 4 months · monthly snapshot~Jan 2022 – ~May 2022 · 4 months · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~May 2023 · 5 months · monthly snapshot~May 2023 – ~Aug 2023 · 3 months · monthly snapshot~Aug 2023 – ~Oct 2023 · 2 months · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Mar 2024 · 4 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Apr 2025 · 3 months · monthly snapshot~Apr 2025 – ~Jul 2025 · 3 months · monthly snapshot~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshot

Change History

30 versions recorded

  1. Dec 2025 — Present [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  2. Nov 2025 — Dec 2025 [monthly]

    Recruiting PHASE2

  3. Sep 2025 — Nov 2025 [monthly]

    Recruiting PHASE2

  4. Jul 2025 — Sep 2025 [monthly]

    Recruiting PHASE2

  5. Apr 2025 — Jul 2025 [monthly]

    Recruiting PHASE2

▶ Show 25 earlier versions

  1. Jan 2025 — Apr 2025 [monthly]

    Recruiting PHASE2

  2. Dec 2024 — Jan 2025 [monthly]

    Recruiting PHASE2

  3. Sep 2024 — Dec 2024 [monthly]

    Recruiting PHASE2

  4. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  5. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE2

  6. Mar 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  7. Nov 2023 — Mar 2024 [monthly]

    Recruiting PHASE2

  8. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE2

  9. Aug 2023 — Oct 2023 [monthly]

    Recruiting PHASE2

  10. May 2023 — Aug 2023 [monthly]

    Recruiting PHASE2

  11. Dec 2022 — May 2023 [monthly]

    Recruiting PHASE2

  12. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE2

  13. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE2

  14. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  15. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  16. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  17. Jan 2022 — May 2022 [monthly]

    Recruiting PHASE2

  18. Sep 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  19. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  20. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  21. Mar 2021 — May 2021 [monthly]

    Recruiting PHASE2

  22. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  23. Oct 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  24. Aug 2020 — Oct 2020 [monthly]

    Not Yet Recruiting PHASE2

  25. Jun 2020 — Aug 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • H. Lee Moffitt Cancer Center and Research Institute
  • National Pediatric Cancer Foundation
Data source: H. Lee Moffitt Cancer Center and Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aurora, United States , Birmingham, United States , Buffalo, United States , Chapel Hill, United States , Charlotte, United States , Cleveland, United States , Columbus, United States , Dallas, United States , Durham, United States , Gainesville, United States and 8 more locations