PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
Phase 1 Study: PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
Sponsor: National Institute of Mental Health (NIMH)
A observational or N/A phase clinical study on ALS and Alzheimer's Disease, this trial is actively recruiting participants. The trial is conducted by National Institute of Mental Health (NIMH) and has accumulated 42 data snapshots since 2021. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.
Study Description(click to expand)Study Description:
This pilot/exploratory study will examine whether cyclooxygenase 1 (COX-1) and COX-2 are elevated in the brain of individuals with neurodegenerative brain disease compared to healthy volunteers.
Objectives:
Primary Objective: To determine whether COX-1 and/or COX-2 is elevated in the brains of individuals with neurodegenerative brain disease compared to healthy volunteers.
Secondary Objective:
1\) To determine retest variability and reliability for each radioligand. 2) To evaluate the specific binding of \[11C\]PS13 to COX-1 in healthy subjects through blocking study using Ketoprofen, a COX-1 inhibitor
Endpoints:
Primary Endpoint: Measurement of COX-1 and COX-2 density in brain after PET scans with \[11C\]PS13 and \[11C\]MC1, respectively.
Secondary endpoint: 1) To measure whole-brain distribution volume (VT) of COX-1 and COX-2 in a retest setting; 2) To correlate VT with the presence of amyloid in Alzheimer s disease (AD) patients, mild cognitive impairment (MCI) patients and healthy volunteers (HV); 3) To calculate the specific binding of \[11C\]PS13 with a Lassen plot
Study Description:
This pilot/exploratory study will examine whether cyclooxygenase 1 (COX-1) and COX-2 are elevated in the brain of individuals with neurodegenerative brain disease compared to healthy volunteers.
Objectives:
Primary Objective: To determine whether COX-1 and/or COX-2 is elevated in the brains of individuals with neurodegenerative brain disease compared to healthy volunteers.
Secondary Objective:
1\) To determine retest variability and reliability for each radioligand. 2) To evaluate the specific binding of \[11C\]PS13 to COX-1 in healthy subjects through blocking study using Ketoprofen, a COX-1 inhibitor
Endpoints:
Primary Endpoint: Measurement of COX-1 and COX-2 density in brain after PET scans with \[11C\]PS13 and \[11C\]MC1, respectively.
Secondary endpoint: 1) To measure whole-brain distribution volume (VT) of COX-1 and COX-2 in a retest setting; 2) To correlate VT with the presence of amyloid in Alzheimer s disease (AD) patients, mild cognitive impairment (MCI) patients and healthy volunteers (HV); 3) To calculate the specific binding of \[11C\]PS13 with a Lassen plot
Status Flow
Change History
42 versions recorded-
Apr 28, 2026 — Present [daily]
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First recorded
Eligibility Summary
Background: About 5 million adults in the U.S. have Alzheimer s disease or another adult-onset neurodegenerative disorder. Many studies have found that inflammation in the brain contributes to these diseases. Researchers want to find a better way to measure this inflammation. Objective: To learn whether COX-1 and/or COX-2 is elevated in the brains of individuals with neurodegenerative brain disease compared to healthy volunteers. Eligibility: Adults age 18 years and older in good general health who have an adult-onset neurodegenerative dementia, such as AD, FTD, corticobasal syndrome, Huntington s disease, or MCI, ALS and healthy adult volunteers enrolled in protocols 01-M-0254 or 17-M-0181. Design: Participants will be screened with medical history, physical exam with vital signs, and lab tests. They will have a neuropsychological testing. Their heart function will be measured. Participants will have a magnetic resonance imaging (MRI) scan. The MRI scanner is a metal tube surrounded by a strong magnetic field. Participants will lie on a table that slides in and out of the tube. The machine makes noise. Participants will get earplugs. Participants will have 2 PET scans. They will be injected with the study drugs through an intravenous catheter placed in an arm vein. The PET scanner is shaped like a doughnut. Participants will lie on a bed that slides in and out of the scanner. A plastic mask will be molded to their head to keep them from moving. A thin plastic tube will be put into an artery at the wrist or elbow crease area. This will be used to draw blood during the scan. Participants will have 2-5 study visits. Participation lasts 1 week to 4 months, depending on scheduling.
Contact Information
- National Institute of Mental Health (NIMH)
For direct contact, visit the study record on ClinicalTrials.gov .