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Terminated PHASE1 INTERVENTIONAL 4-arm NCT03912428

Novel PET Radioligand as an Inflammatory Biomarker in Musculoskeletal Conditions

Evaluation of a Novel PET Radioligand as an Inflammatory Biomarker in Musculoskeletal Conditions

Sponsor: National Institute of Mental Health (NIMH)

Conditions Healthy Volunteers Inflammatory Myositis Rheumatoid Arthritis
Interventions 11C-MC1 Celecoxib Positron Emission Tomography (PET)/computed tomography (CT) Scan [11C]ER176
Updated 42 times since 2019 Last updated: Aug 28, 2025 Started: Jun 14, 2019 Primary completion: Jun 14, 2024 Completion: Jun 14, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

due to difficulty with participant recruitment and data futility

Other terminated trials from National Institute of Mental Health (NIMH)

See all terminations from National Institute of Mental Health (NIMH)

Other Healthy Volunteers trials with similar outcome

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Listed as NCT03912428, this PHASE1 trial focuses on Healthy Volunteers and Inflammatory and remains terminated or withdrawn. Sponsored by National Institute of Mental Health (NIMH), it has been updated 42 times since 2019, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Jan 2020 · 6 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~May 2020 · 3 months · monthly snapshot~May 2020 – ~Nov 2020 · 6 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Mar 2022 · 4 months · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Feb 2023 · 3 months · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Jul 2023 · 4 months · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Oct 2023 · 2 months · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~Oct 2025 · 6 months · monthly snapshot~Oct 2025 – present · 11 months · monthly snapshot

Change History

42 versions recorded

  1. Oct 2025 — Present [monthly]

    Terminated PHASE1

    Status: Active Not Recruiting → Terminated

  2. Apr 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  3. Mar 2025 — Apr 2025 [monthly]

    Recruiting PHASE1

  4. Feb 2025 — Mar 2025 [monthly]

    Recruiting PHASE1

  5. Jan 2025 — Feb 2025 [monthly]

    Recruiting PHASE1

▶ Show 37 earlier versions

  1. Dec 2024 — Jan 2025 [monthly]

    Recruiting PHASE1

  2. Nov 2024 — Dec 2024 [monthly]

    Recruiting PHASE1

  3. Oct 2024 — Nov 2024 [monthly]

    Recruiting PHASE1

  4. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE1

  5. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  6. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE1

  7. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

  8. May 2024 — Jun 2024 [monthly]

    Recruiting PHASE1

  9. Apr 2024 — May 2024 [monthly]

    Recruiting PHASE1

  10. Mar 2024 — Apr 2024 [monthly]

    Recruiting PHASE1

  11. Feb 2024 — Mar 2024 [monthly]

    Recruiting PHASE1

  12. Jan 2024 — Feb 2024 [monthly]

    Recruiting PHASE1

  13. Dec 2023 — Jan 2024 [monthly]

    Recruiting PHASE1

  14. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE1

  15. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE1

  16. Aug 2023 — Oct 2023 [monthly]

    Recruiting PHASE1

  17. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE1

  18. Mar 2023 — Jul 2023 [monthly]

    Recruiting PHASE1

  19. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE1

  20. Nov 2022 — Feb 2023 [monthly]

    Recruiting PHASE1

  21. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE1

    Phase: PHASE1_PHASE2 → PHASE1

  22. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE1_PHASE2

  23. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE1_PHASE2

  24. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE1_PHASE2

  25. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1_PHASE2

  26. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE1_PHASE2

  27. Nov 2021 — Mar 2022 [monthly]

    Recruiting PHASE1_PHASE2

  28. Sep 2021 — Nov 2021 [monthly]

    Recruiting PHASE1_PHASE2

  29. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE1_PHASE2

    Phase: PHASE4 → PHASE1_PHASE2

  30. Jan 2021 — May 2021 [monthly]

    Recruiting PHASE4

  31. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE4

    Phase: PHASE3 → PHASE4

  32. May 2020 — Nov 2020 [monthly]

    Recruiting PHASE3

    Phase: PHASE1 → PHASE3

  33. Feb 2020 — May 2020 [monthly]

    Recruiting PHASE1

  34. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  35. Jul 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  36. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  37. May 2019 — Jun 2019 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Institute of Mental Health (NIMH)
Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations