A Study to Assess the Safety, Tolerability, and Efficacy of ION-827359 in Participants With Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis (CB)
A Double-Blind, Placebo-Controlled, Phase 2a Study to Assess the Safety, Tolerability, and Efficacy of ION-827359 in Patients With Mild to Moderate COPD With Chronic Bronchitis
Sponsor: Ionis Pharmaceuticals, Inc.
Terminated
Business Decision to Terminate Study
Other terminated trials from Ionis Pharmaceuticals, Inc.
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More terminations from Ionis Pharmaceuticals, Inc.
Other Chronic Bronchitis trials with similar outcome
This PHASE2 trial investigates Chronic Bronchitis and Chronic Obstructive Pulmonary Disease and is currently terminated or withdrawn. Ionis Pharmaceuticals, Inc. leads this study, which shows 11 recorded versions since 2020 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.
Status Flow
Change History
11 versions recorded-
Sep 2025 — Present [monthly]
Terminated PHASE2
-
Sep 2024 — Sep 2025 [monthly]
Terminated PHASE2
-
Jul 2024 — Sep 2024 [monthly]
Terminated PHASE2
-
Jan 2023 — Jul 2024 [monthly]
Terminated PHASE2
-
Jun 2021 — Jan 2023 [monthly]
Terminated PHASE2
Status: Recruiting → Terminated
▶ Show 6 earlier versions
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Apr 2021 — Jun 2021 [monthly]
Recruiting PHASE2
-
Feb 2021 — Apr 2021 [monthly]
Recruiting PHASE2
-
Jan 2021 — Feb 2021 [monthly]
Recruiting PHASE2
-
Dec 2020 — Jan 2021 [monthly]
Recruiting PHASE2
Status: Not Yet Recruiting → Recruiting
-
Nov 2020 — Dec 2020 [monthly]
Not Yet Recruiting PHASE2
-
Jul 2020 — Nov 2020 [monthly]
Not Yet Recruiting PHASE2
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- Ionis Pharmaceuticals, Inc.
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
Berlin, Germany , Deszk, Hungary , Großhansdorf, Germany , Hamburg, Germany , Jindřichův Hradec, Czechia , Komárom, Hungary , Kralupy nad Vltavou, Czechia , London, United Kingdom , Lovosice, Czechia , Lübeck, Germany and 4 more locations