deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT04469270

Study to Assess Safety and Efficacy of Engensis in Painful Diabetic Peripheral Neuropathy (REGAiN-1A)

An Adaptive, Phase 3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Safety and Efficacy of Engensis in Participants With Painful Diabetic Peripheral Neuropathy

Sponsor: Helixmith Co., Ltd.

Interventions Engensis Placebo
Updated 13 times since 2020 Last updated: Sep 23, 2025 Started: Nov 20, 2020 Primary completion: Mar 24, 2023 Completion: Jul 31, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04469270, this PHASE3 trial focuses on Diabetic Neuropathy, Painful and remains completed. Sponsored by Helixmith Co., Ltd., it has been updated 13 times since 2020, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Aug 2020 – ~Dec 2020 · 4 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Jun 2021 · 4 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Sep 2022 · 9 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Jul 2024 · 19 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Nov 2025 · 9 months · monthly snapshot~Nov 2025 – present · 10 months · monthly snapshot

Change History

13 versions recorded
  1. Nov 2025 — Present [monthly]

    Completed PHASE3

  2. Feb 2025 — Nov 2025 [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

  3. Sep 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  5. Dec 2022 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

Show 8 earlier versions
  1. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  2. Dec 2021 — Sep 2022 [monthly]

    Recruiting PHASE3

  3. Sep 2021 — Dec 2021 [monthly]

    Recruiting PHASE3

  4. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  5. Feb 2021 — Jun 2021 [monthly]

    Recruiting PHASE3

  6. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  7. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  8. Aug 2020 — Dec 2020 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Helixmith Co., Ltd.
Data source: Helixmith Co., Ltd.

For direct contact, visit the study record on ClinicalTrials.gov .