deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT04476329

Optimization for Regorafenib in HCC (ReDos HCC)

A Randomized Phase II Study of First Cycle Optimization for Regorafenib Treatment Compared to Standard Dose of Regorafenib in Patients With HCC Who Failed Any 1st Line Systemic Treatment and for Whom the Physician is Intending to Treat With Regorafenib

Sponsor: Bayer

Interventions Regorafenib 40 MG
Updated 11 times since 2020 Last updated: Dec 10, 2021 Started: Jan 21, 2021 Primary completion: Oct 13, 2021 Completion: Dec 10, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Enrollment rate not sufficient to meet funding entity's corporation timeline expectations, entity terminated study's fiscal support. Termination decision was purely administrative in nature and did not involve drug or patient safety issues.

Listed as NCT04476329, this PHASE2 trial focuses on Hepatocellular Carcinoma and remains terminated or withdrawn. Sponsored by Bayer, it has been updated 11 times since 2021, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Aug 2020 – ~Nov 2020 · 3 months · monthly snapshotNot Yet Recruiting~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshotNot Yet Recruiting~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshotRecruiting~Apr 2021 – ~May 2021 · 30 days · monthly snapshotRecruiting~May 2021 – ~Sep 2021 · 4 months · monthly snapshotRecruiting~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshotRecruiting~Nov 2021 – ~Jan 2022 · 2 months · monthly snapshotActive Not Recruiting~Jan 2022 – ~Jul 2024 · 30 months · monthly snapshotTerminated~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotTerminated~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotTerminated~Sep 2025 – present · 10 months · monthly snapshotTerminated

Change History

11 versions recorded
  1. Sep 2025 — Present [monthly]

    Terminated PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

  4. Jan 2022 — Jul 2024 [monthly]

    Terminated PHASE2

    Status: Active Not RecruitingTerminated

  5. Nov 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

Show 6 earlier versions
  1. Sep 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  2. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  3. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE2

  4. Jan 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  5. Nov 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE2

  6. Aug 2020 — Nov 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bayer
  • SC Liver Research Consortium, LLC
Data source: SC Liver Research Consortium, LLC

For direct contact, visit the study record on ClinicalTrials.gov .