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Completed PHASE2 INTERVENTIONAL 3-arm NCT04491955

Phase II Trial of Combination Immunotherapy in Subjects With Advanced Small Bowel and Colorectal Cancers

Sponsor: National Cancer Institute (NCI)

Conditions Colorectal Cancers Small Bowel Cancers
Interventions CV301 MSB0011359C N-803 NHS-IL12
Updated 30 times since 2020 Last updated: Apr 7, 2025 Started: Sep 22, 2020 Primary completion: Oct 25, 2022 Completion: Aug 16, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Colorectal Cancers and Small Bowel Cancers, this trial is completed. The trial is conducted by National Cancer Institute (NCI) and has accumulated 30 data snapshots since 2020. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Jan 2022 · 2 months · monthly snapshot~Jan 2022 – ~Apr 2022 · 3 months · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~Dec 2023 · 8 months · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Dec 2024 · 2 months · monthly snapshot~Dec 2024 – ~Apr 2025 · 4 months · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – present · 14 months · monthly snapshot

Change History

30 versions recorded

  1. May 2025 — Present [monthly]

    Completed PHASE2

  2. Apr 2025 — May 2025 [monthly]

    Completed PHASE2

  3. Dec 2024 — Apr 2025 [monthly]

    Completed PHASE2

  4. Oct 2024 — Dec 2024 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  5. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE2

▶ Show 25 earlier versions

  1. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Dec 2023 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: Completed → Active Not Recruiting

  4. Apr 2023 — Dec 2023 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  5. Feb 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE2

  6. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  7. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE2

  8. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE2

  9. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE2

  10. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  11. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  12. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  13. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE2

  14. Jan 2022 — Apr 2022 [monthly]

    Recruiting PHASE2

    Status: Suspended → Recruiting

  15. Nov 2021 — Jan 2022 [monthly]

    Suspended PHASE2

    Status: Recruiting → Suspended

  16. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  17. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  18. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  19. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE2

  20. Feb 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  21. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  22. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  23. Oct 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  24. Sep 2020 — Oct 2020 [monthly]

    Not Yet Recruiting PHASE2

  25. Aug 2020 — Sep 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Institutes of Health Clinical Center (CC)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations