deltatrials
Completed PHASE1 INTERVENTIONAL 3-arm NCT04501276

A Phase 1b/2 Study of ADG116, ADG116 Combined With Anti-PD-1 Antibody or Anti-CD137 Antibody in Solid Tumors Patients

A Phase 1b/2, Open-Label, Dose Escalation and Expansion Study of ADG116, ADG116 Combined With Toripalimab (Anti-PD-1 Antibody), ADG116 Combined With ADG106 (Anti-CD137 Antibody) in Patients With Advanced/Metastatic Solid Tumors

Sponsor: Adagene Inc

Conditions Advanced/Metastatic Solid Tumors
Interventions ADG106 ADG116 anti PD1 drug
Updated 9 times since 2020 Last updated: Jan 6, 2026 Started: Sep 23, 2020 Primary completion: Jan 17, 2024 Completion: Nov 30, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Advanced/Metastatic Solid Tumors, this trial is completed. The trial is conducted by Adagene Inc and has accumulated 9 data snapshots since 2020. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Mar 2022 · 14 months · monthly snapshotRecruiting~Mar 2022 – ~May 2023 · 14 months · monthly snapshotRecruiting~May 2023 – ~Feb 2024 · 9 months · monthly snapshotRecruiting~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2026 · 17 months · monthly snapshotActive Not Recruiting~Feb 2026 – present · 5 months · monthly snapshot

Change History

9 versions recorded

  1. Feb 2026 — Present [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  2. Sep 2024 — Feb 2026 [monthly]

    Active Not Recruiting PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Feb 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  5. May 2023 — Feb 2024 [monthly]

    Recruiting PHASE1

▶ Show 4 earlier versions

  1. Mar 2022 — May 2023 [monthly]

    Recruiting PHASE1

  2. Jan 2021 — Mar 2022 [monthly]

    Recruiting PHASE1

  3. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  4. Sep 2020 — Nov 2020 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Adagene Inc
Data source: Adagene Inc

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations