Study Evaluating the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD), and Therapeutic Activity of Selicrelumab (RO7009789) With Vanucizumab or Bevacizumab in Participants With Metastatic Solid Tumors
An Open-Label, Multicenter, Dose Escalation Phase Ib Study With Expansion Cohorts to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Therapeutic Activity of RO7009789 (CD40 Agonistic Monoclonal Antibody) in Combination With Vanucizumab (Anti-Ang2 and Anti-VEGF Bi-Specific Monoclonal Antibody, Part I) or Bevacizumab (Anti-VEGF Monoclonal Antibody, Part II) in Patients With Metastatic Solid Tumors
Sponsor: Hoffmann-La Roche
This PHASE1 trial investigates Advanced/Metastatic Solid Tumors and is currently completed. Hoffmann-La Roche leads this study, which shows 22 recorded versions since 2016 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.
Status Flow
Change History
22 versions recorded-
Sep 2025 — Present [monthly]
Completed PHASE1
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Sep 2024 — Sep 2025 [monthly]
Completed PHASE1
-
Jul 2024 — Sep 2024 [monthly]
Completed PHASE1
-
Jan 2021 — Jul 2024 [monthly]
Completed PHASE1
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May 2020 — Jan 2021 [monthly]
Completed PHASE1
▶ Show 17 earlier versions
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Feb 2020 — May 2020 [monthly]
Completed PHASE1
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Dec 2019 — Feb 2020 [monthly]
Completed PHASE1
Status: Active Not Recruiting → Completed
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Nov 2019 — Dec 2019 [monthly]
Active Not Recruiting PHASE1
Status: Recruiting → Active Not Recruiting
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Jul 2019 — Nov 2019 [monthly]
Recruiting PHASE1
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May 2019 — Jul 2019 [monthly]
Recruiting PHASE1
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Apr 2019 — May 2019 [monthly]
Recruiting PHASE1
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Mar 2019 — Apr 2019 [monthly]
Recruiting PHASE1
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Feb 2019 — Mar 2019 [monthly]
Recruiting PHASE1
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Nov 2018 — Feb 2019 [monthly]
Recruiting PHASE1
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Aug 2018 — Nov 2018 [monthly]
Recruiting PHASE1
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Jul 2018 — Aug 2018 [monthly]
Recruiting PHASE1
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Jun 2018 — Jul 2018 [monthly]
Recruiting PHASE1
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Aug 2017 — Jun 2018 [monthly]
Recruiting PHASE1
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Jul 2017 — Aug 2017 [monthly]
Recruiting PHASE1
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Apr 2017 — Jul 2017 [monthly]
Recruiting PHASE1
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Feb 2017 — Apr 2017 [monthly]
Recruiting PHASE1
-
Jan 2017 — Feb 2017 [monthly]
Recruiting PHASE1
First recorded
Jan 2016
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Hoffmann-La Roche
For direct contact, visit the study record on ClinicalTrials.gov .