deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT04522180

A Study to Assess the Safety, Tolerability, and Efficacy of IONIS-GHR-LRx Administered in Patients With Acromegaly

An Open Label, Randomized, Phase 2 Study to Assess the Safety, Tolerability, and Efficacy of IONIS-GHR-LRx, an Antisense Inhibitor of the Growth Hormone Receptor, Administered Monthly as Monotherapy in Patients With Acromegaly

Sponsor: Ionis Pharmaceuticals, Inc.

Conditions Acromegaly
Interventions GHR-LRX
Updated 17 times since 2020 Last updated: Sep 26, 2024 Started: Jan 4, 2021 Primary completion: Jul 15, 2022 Completion: May 4, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Acromegaly, this trial is completed. The trial is conducted by Ionis Pharmaceuticals, Inc. and has accumulated 17 data snapshots since 2021. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~Jun 2021 · 2 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Feb 2022 · 3 months · monthly snapshot~Feb 2022 – ~Sep 2022 · 7 months · monthly snapshot~Sep 2022 – ~Jul 2023 · 10 months · monthly snapshot~Jul 2023 – ~Jul 2024 · 12 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Sep 2025 · 10 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

17 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Nov 2024 — Sep 2025 [monthly]

    Completed PHASE2

  3. Sep 2024 — Nov 2024 [monthly]

    Completed PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  5. Jul 2023 — Jul 2024 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

Show 12 earlier versions
  1. Sep 2022 — Jul 2023 [monthly]

    Active Not Recruiting PHASE2

  2. Feb 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  3. Nov 2021 — Feb 2022 [monthly]

    Recruiting PHASE2

  4. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  5. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  6. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  7. Apr 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  8. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  9. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  10. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  11. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  12. Sep 2020 — Nov 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Ionis Pharmaceuticals, Inc.
Data source: Ionis Pharmaceuticals, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .