deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 2-arm NCT04572815

Ustekinumab for the Prevention of Acute Graft-versus-Host Disease After Unrelated Donor Hematopoietic Cell Transplant

Randomized, Placebo-Controlled, Phase II Trial Examining Ustekinumab for Prevention of Graft Vs. Host Disease After Allogeneic Hematopoietic Cell Transplantation

Sponsor: Fred Hutchinson Cancer Center

Conditions Hematologic and Lymphocytic Disorder Hematopoietic and Lymphoid System Neoplasm
Interventions Placebo Administration Quality-of-Life Assessment Questionnaire Administration Ustekinumab
Updated 26 times since 2020 Last updated: Dec 30, 2025 Started: May 14, 2021 Primary completion: Oct 27, 2025 Completion: Jun 30, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04572815, this PHASE2 trial focuses on Hematologic and Lymphocytic Disorder and Hematopoietic and Lymphoid System Neoplasm and remains ongoing. Sponsored by Fred Hutchinson Cancer Center, it has been updated 26 times since 2021, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Feb 2022 · 3 months · monthly snapshot~Feb 2022 – ~Apr 2022 · 59 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Sep 2022 · 4 months · monthly snapshot~Sep 2022 – ~Jan 2023 · 4 months · monthly snapshot~Jan 2023 – ~Apr 2023 · 3 months · monthly snapshot~Apr 2023 – ~Nov 2023 · 7 months · monthly snapshot~Nov 2023 – ~Mar 2024 · 4 months · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~Jun 2024 · 2 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Jun 2025 · 4 months · monthly snapshot~Jun 2025 – ~Dec 2025 · 6 months · monthly snapshot~Dec 2025 – ~Feb 2026 · 2 months · monthly snapshot~Feb 2026 – present · 7 months · monthly snapshot

Change History

26 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Dec 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Jun 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  4. Feb 2025 — Jun 2025 [monthly]

    Recruiting PHASE2

  5. Sep 2024 — Feb 2025 [monthly]

    Recruiting PHASE2

▶ Show 21 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  2. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  3. Apr 2024 — Jun 2024 [monthly]

    Recruiting PHASE2

  4. Mar 2024 — Apr 2024 [monthly]

    Recruiting PHASE2

    Status: Suspended → Recruiting

  5. Nov 2023 — Mar 2024 [monthly]

    Suspended PHASE2

    Status: Recruiting → Suspended

  6. Apr 2023 — Nov 2023 [monthly]

    Recruiting PHASE2

  7. Jan 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

  8. Sep 2022 — Jan 2023 [monthly]

    Recruiting PHASE2

  9. May 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  10. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE2

  11. Feb 2022 — Apr 2022 [monthly]

    Recruiting PHASE2

  12. Nov 2021 — Feb 2022 [monthly]

    Recruiting PHASE2

  13. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  14. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  15. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  16. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  17. Apr 2021 — May 2021 [monthly]

    Not Yet Recruiting PHASE2

  18. Mar 2021 — Apr 2021 [monthly]

    Not Yet Recruiting PHASE2

  19. Feb 2021 — Mar 2021 [monthly]

    Not Yet Recruiting PHASE2

  20. Jan 2021 — Feb 2021 [monthly]

    Not Yet Recruiting PHASE2

  21. Oct 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Fred Hutchinson Cancer Center
Data source: Fred Hutchinson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations