deltatrials
Completed NA INTERVENTIONAL 2-arm NCT04593810

Effect of Automated Closed-Loop Ventilation Versus Conventional Ventilation on Duration and Quality of Ventilation (ACTiVE)

Effect of Automated Closed-Loop Ventilation Versus Conventional Ventilation on Duration and Quality of Ventilation ('ACTiVE') - a Randomized Clinical Trial in Intensive Care Unit Patients

Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Updated 12 times since 2020 Last updated: Mar 9, 2026 Started: Oct 19, 2020 Primary completion: Jul 16, 2025 Completion: Sep 16, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This NA trial investigates Quality of Breathing and Ventilator-free Days and is currently completed. Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) leads this study, which shows 12 recorded versions since 2020 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshotRecruiting~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshotRecruiting~Oct 2021 – ~Apr 2022 · 6 months · monthly snapshotRecruiting~Apr 2022 – ~Aug 2023 · 16 months · monthly snapshotRecruiting~Aug 2023 – ~Jul 2024 · 11 months · monthly snapshotRecruiting~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshotRecruiting~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshotRecruiting~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshotRecruiting~Feb 2025 – ~Sep 2025 · 7 months · monthly snapshotRecruiting~Sep 2025 – ~Jan 2026 · 4 months · monthly snapshotRecruiting~Jan 2026 – ~Mar 2026 · 59 days · monthly snapshotCompleted~Mar 2026 – present · 4 months · monthly snapshotCompleted

Change History

12 versions recorded
  1. Mar 2026 — Present [monthly]

    Completed NA

  2. Jan 2026 — Mar 2026 [monthly]

    Completed NA

    Status: RecruitingCompleted

  3. Sep 2025 — Jan 2026 [monthly]

    Recruiting NA

  4. Feb 2025 — Sep 2025 [monthly]

    Recruiting NA

  5. Sep 2024 — Feb 2025 [monthly]

    Recruiting NA

Show 7 earlier versions
  1. Aug 2024 — Sep 2024 [monthly]

    Recruiting NA

  2. Jul 2024 — Aug 2024 [monthly]

    Recruiting NA

  3. Aug 2023 — Jul 2024 [monthly]

    Recruiting NA

  4. Apr 2022 — Aug 2023 [monthly]

    Recruiting NA

  5. Oct 2021 — Apr 2022 [monthly]

    Recruiting NA

  6. Jan 2021 — Oct 2021 [monthly]

    Recruiting NA

  7. Nov 2020 — Jan 2021 [monthly]

    Recruiting NA

    First recorded

Oct 2020

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
  • Canisius-Wilhelmina Hospital
  • Catharina Ziekenhuis Eindhoven
  • Diakonessenhuis, Utrecht
  • Elisabeth-TweeSteden Ziekenhuis
  • Flevoziekenhuis
  • Fondazione IRCCS Policlinico San Matteo di Pavia
  • Leiden University Medical Center
  • Ospedale Policlinico San Martino
  • Prof. Dr. Marcus J. Schultz
  • Reinier de Graaf Groep
  • ZonMw: The Netherlands Organisation for Health Research and Development
Data source: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

For direct contact, visit the study record on ClinicalTrials.gov .