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Terminated PHASE3 INTERVENTIONAL 1-arm NCT04732286

A Study of Atezolizumab in Combination With Bevacizumab in Spanish Patients With Unresectable or Unsuitable for Locoregional Treatments Hepatocellular Carcinoma Not Previously Treated With Systemic Therapy

A Phase IIIb, Single Arm, Multicenter Study of Atezolizumab in Combination With Bevacizumab to Investigate Safety and Efficacy in Spanish Patients With Unresectable or Unsuitable for Locoregional Treatments Hepatocellular Carcinoma Not Previously Treated With Systemic Therapy

Sponsor: Hoffmann-La Roche

Updated 27 times since 2021 Last updated: Apr 22, 2025 Started: May 4, 2021 Primary completion: Apr 26, 2024 Completion: Apr 26, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

The study was completed as pre-specified in the protocol. Study was terminated only for participants who were in the study even after 24 months of follow-up as specified in the protocol.

Listed as NCT04732286, this PHASE3 trial focuses on Carcinoma, Hepatocellular and remains terminated or withdrawn. Sponsored by Hoffmann-La Roche, it has been updated 27 times since 2021, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Jan 2023 · 4 months · monthly snapshot~Jan 2023 – ~Apr 2023 · 3 months · monthly snapshot~Apr 2023 – ~Jun 2023 · 2 months · monthly snapshot~Jun 2023 – ~Sep 2023 · 3 months · monthly snapshot~Sep 2023 – ~Dec 2023 · 3 months · monthly snapshot~Dec 2023 – ~Mar 2024 · 3 months · monthly snapshot~Mar 2024 – ~Jun 2024 · 3 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jun 2025 · 9 months · monthly snapshot~Jun 2025 – ~Sep 2025 · 3 months · monthly snapshot~Sep 2025 – present · 12 months · monthly snapshot

Change History

27 versions recorded
  1. Sep 2025 — Present [monthly]

    Terminated PHASE3

  2. Jun 2025 — Sep 2025 [monthly]

    Terminated PHASE3

    Status: CompletedTerminated

  3. Sep 2024 — Jun 2025 [monthly]

    Completed PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  5. Jun 2024 — Jul 2024 [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

Show 22 earlier versions
  1. Mar 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE3

  2. Dec 2023 — Mar 2024 [monthly]

    Active Not Recruiting PHASE3

  3. Sep 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE3

  4. Jun 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE3

  5. Apr 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE3

  6. Jan 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE3

  7. Sep 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE3

  8. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  9. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  10. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE3

  11. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE3

  12. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE3

  13. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE3

  14. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE3

  15. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE3

  16. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE3

  17. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE3

  18. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE3

  19. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  20. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  21. Apr 2021 — May 2021 [monthly]

    Not Yet Recruiting PHASE3

  22. Mar 2021 — Apr 2021 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Hoffmann-La Roche
Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .