deltatrials
Completed PHASE3 INTERVENTIONAL 1-arm NCT04739059

Long-term Safety and Efficacy of CSL312 (Garadacimab) in the Prophylactic Treatment of Hereditary Angioedema Attacks

An Open-label Study to Evaluate the Long-term Safety and Efficacy of CSL312 (Garadacimab) in the Prophylactic Treatment of Hereditary Angioedema

Sponsor: CSL Behring

Interventions CSL312
Updated 51 times since 2021 Last updated: Jan 23, 2026 Started: Apr 29, 2021 Primary completion: Nov 21, 2025 Completion: Nov 21, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Hereditary Angioedema, this trial is completed. The trial is conducted by CSL Behring and has accumulated 51 data snapshots since 2021. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Feb 2026 · 5 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

51 versions recorded
  1. Feb 2026 — Present [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

  2. Sep 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE3

  3. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Jul 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Jun 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE3

Show 46 earlier versions
  1. May 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE3

  2. Apr 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Mar 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Jan 2025 — Feb 2025 [monthly]

    Active Not Recruiting PHASE3

  6. Dec 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE3

  7. Nov 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE3

  8. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE3

  9. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE3

  10. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  11. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE3

  12. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  13. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE3

  14. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE3

  15. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE3

  16. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE3

  17. Jan 2024 — Feb 2024 [monthly]

    Active Not Recruiting PHASE3

  18. Dec 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE3

  19. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE3

  20. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

  21. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE3

  22. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE3

  23. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE3

  24. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE3

  25. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE3

  26. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  27. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE3

  28. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE3

  29. Dec 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE3

  30. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE3

  31. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  32. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE3

  33. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

  34. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE3

  35. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE3

  36. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE3

  37. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE3

  38. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE3

  39. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE3

  40. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE3

  41. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE3

  42. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE3

  43. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  44. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  45. Apr 2021 — May 2021 [monthly]

    Not Yet Recruiting PHASE3

  46. Mar 2021 — Apr 2021 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • CSL Behring
Data source: CSL Behring

For direct contact, visit the study record on ClinicalTrials.gov .