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Terminated PHASE2 INTERVENTIONAL 2-arm NCT04854096

Study to Assess Efficacy and Safety of NS-018 Compared to BAT in Patients With Myelofibrosis

A Phase 2b, Open-label, Multicenter, Randomized, Controlled, 2-Arm Study to Assess the Efficacy and Safety of Orally Administered NS-018 Versus Best Available Therapy in Subjects With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis With Severe Thrombocytopenia (Platelet Count <50,000/μL)

Sponsor: NS Pharma, Inc.

Updated 20 times since 2021 Last updated: May 22, 2025 Started: Jan 31, 2023 Primary completion: May 16, 2024 Completion: May 16, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

The study was stopped due to a business decision.

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This PHASE2 trial investigates Post-essential Thrombocythemia Myelofibrosis and Post-polycythemia Vera Myelofibrosis and is currently terminated or withdrawn. NS Pharma, Inc. leads this study, which shows 20 recorded versions since 2023 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~May 2021 – ~Oct 2021 · 5 months · monthly snapshot~Oct 2021 – ~Dec 2021 · 2 months · monthly snapshot~Dec 2021 – ~May 2022 · 5 months · monthly snapshot~May 2022 – ~Sep 2022 · 4 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Mar 2023 · 3 months · monthly snapshot~Mar 2023 – ~May 2023 · 2 months · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Aug 2023 · 2 months · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Nov 2023 · 2 months · monthly snapshot~Nov 2023 – ~Jan 2024 · 2 months · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~May 2024 · 3 months · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jun 2025 · 9 months · monthly snapshot~Jun 2025 – ~Sep 2025 · 3 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

20 versions recorded
  1. Sep 2025 — Present [monthly]

    Terminated PHASE2

  2. Jun 2025 — Sep 2025 [monthly]

    Terminated PHASE2

  3. Sep 2024 — Jun 2025 [monthly]

    Terminated PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

    Status: RecruitingTerminated

  5. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

Show 15 earlier versions
  1. May 2024 — Jun 2024 [monthly]

    Recruiting PHASE2

  2. Feb 2024 — May 2024 [monthly]

    Recruiting PHASE2

  3. Jan 2024 — Feb 2024 [monthly]

    Recruiting PHASE2

  4. Nov 2023 — Jan 2024 [monthly]

    Recruiting PHASE2

  5. Sep 2023 — Nov 2023 [monthly]

    Recruiting PHASE2

  6. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE2

  7. Jun 2023 — Aug 2023 [monthly]

    Recruiting PHASE2

  8. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE2

  9. Mar 2023 — May 2023 [monthly]

    Recruiting PHASE2

  10. Dec 2022 — Mar 2023 [monthly]

    Recruiting PHASE2

  11. Sep 2022 — Dec 2022 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  12. May 2022 — Sep 2022 [monthly]

    Not Yet Recruiting PHASE2

  13. Dec 2021 — May 2022 [monthly]

    Not Yet Recruiting PHASE2

  14. Oct 2021 — Dec 2021 [monthly]

    Not Yet Recruiting PHASE2

  15. May 2021 — Oct 2021 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • NS Pharma, Inc.
  • Nippon Shinyaku Co., Ltd.
Data source: NS Pharma, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .