deltatrials
Recruiting PHASE4 INTERVENTIONAL 2-arm NCT04875702

Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout (TRUST)

Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout: A Randomized Controlled Trial

Sponsor: Massachusetts General Hospital

Conditions Gout
Interventions Allopurinol Colchicine 0.6 mg Colchicine 1.2 mg Naproxen 250 MG Naproxen 500 Mg Prednisone 40 mg
Updated 9 times since 2021 Last updated: Sep 22, 2025 Started: Feb 22, 2024 Primary completion: Sep 1, 2028 Completion: Oct 31, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Gout and is currently actively recruiting participants. Massachusetts General Hospital leads this study, which shows 9 recorded versions since 2024 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jun 2021 – ~Jul 2023 · 25 months · monthly snapshotNot Yet Recruiting~Jul 2023 – ~Nov 2023 · 4 months · monthly snapshotNot Yet Recruiting~Nov 2023 – ~Apr 2024 · 5 months · monthly snapshotNot Yet Recruiting~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshotRecruiting~Oct 2024 – ~Sep 2025 · 11 months · monthly snapshotRecruiting~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshotRecruiting~Oct 2025 – present · 10 months · monthly snapshotRecruiting

Change History

9 versions recorded

  1. Oct 2025 — Present [monthly]

    Recruiting PHASE4

  2. Sep 2025 — Oct 2025 [monthly]

    Recruiting PHASE4

  3. Oct 2024 — Sep 2025 [monthly]

    Recruiting PHASE4

  4. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE4

  5. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE4

▶ Show 4 earlier versions

  1. Apr 2024 — Jul 2024 [monthly]

    Recruiting PHASE4

    Status: Not Yet Recruiting → Recruiting · Phase: NA → PHASE4

  2. Nov 2023 — Apr 2024 [monthly]

    Not Yet Recruiting NA

  3. Jul 2023 — Nov 2023 [monthly]

    Not Yet Recruiting NA

  4. Jun 2021 — Jul 2023 [monthly]

    Not Yet Recruiting NA

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Massachusetts General Hospital
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Data source: Massachusetts General Hospital

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations