deltatrials
Unknown PHASE3 INTERVENTIONAL 2-arm NCT04905108

Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia

Randomized Study of Safety and Effectiveness of Corneal Collagen Crosslinking Using Two Different Riboflavin Administration Protocols

Sponsor: Cornea and Laser Eye Institute

Interventions Riboflavin
Updated 6 times since 2021 Last updated: Dec 30, 2022 Started: Jun 2, 2021 Primary completion: Jun 30, 2025 Completion: Dec 31, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Corneal Ectasia and Keratoconus and is currently ongoing. Cornea and Laser Eye Institute leads this study, which shows 6 recorded versions since 2021 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshotNot Yet Recruiting~Sep 2021 – ~Feb 2023 · 17 months · monthly snapshotRecruiting~Feb 2023 – ~Jul 2024 · 17 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Feb 2026 · 17 months · monthly snapshotRecruiting~Feb 2026 – present · 5 months · monthly snapshotUnknown

Change History

6 versions recorded
  1. Feb 2026 — Present [monthly]

    Unknown PHASE3

    Status: RecruitingUnknown

  2. Sep 2024 — Feb 2026 [monthly]

    Recruiting PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE3

  4. Feb 2023 — Jul 2024 [monthly]

    Recruiting PHASE3

  5. Sep 2021 — Feb 2023 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

Show 1 earlier version
  1. Jun 2021 — Sep 2021 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Cornea and Laser Eye Institute
Data source: Cornea and Laser Eye Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations