deltatrials
Active Not Recruiting EARLY_PHASE1 INTERVENTIONAL 2-arm NCT04937062

Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy

Sponsor: Children's Hospital Colorado

Updated 11 times since 2021 Last updated: Jan 20, 2026 Started: Mar 1, 2021 Primary completion: Dec 1, 2026 Completion: Dec 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A EARLY_PHASE1 clinical study on Developmental and Epileptic Encephalopathy and STXBP1 Encephalopathy With Epilepsy, SLC6A1 Neurodevelopmental Disorder, this trial is ongoing. The trial is conducted by Children's Hospital Colorado and has accumulated 11 data snapshots since 2021. Psychiatric clinical trials are essential for establishing evidence-based treatment standards.

Status Flow

~Sep 2021 – ~Apr 2022 · 7 months · monthly snapshotRecruiting~Apr 2022 – ~Jun 2022 · 2 months · monthly snapshot~Jun 2022 – ~Oct 2022 · 4 months · monthly snapshot~Oct 2022 – ~Feb 2023 · 4 months · monthly snapshot~Feb 2023 – ~Nov 2023 · 9 months · monthly snapshotActive Not Recruiting~Nov 2023 – ~Jul 2024 · 8 months · monthly snapshotEnrolling By Invitation~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshotEnrolling By Invitation~Feb 2025 – ~Oct 2025 · 8 months · monthly snapshotEnrolling By Invitation~Oct 2025 – ~Feb 2026 · 4 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshotActive Not Recruiting

Change History

11 versions recorded
  1. Feb 2026 — Present [monthly]

    Active Not Recruiting EARLY_PHASE1

  2. Oct 2025 — Feb 2026 [monthly]

    Active Not Recruiting EARLY_PHASE1

    Status: Enrolling By InvitationActive Not Recruiting

  3. Feb 2025 — Oct 2025 [monthly]

    Enrolling By Invitation EARLY_PHASE1

  4. Sep 2024 — Feb 2025 [monthly]

    Enrolling By Invitation EARLY_PHASE1

  5. Jul 2024 — Sep 2024 [monthly]

    Enrolling By Invitation EARLY_PHASE1

Show 6 earlier versions
  1. Nov 2023 — Jul 2024 [monthly]

    Enrolling By Invitation EARLY_PHASE1

    Status: Active Not RecruitingEnrolling By Invitation

  2. Feb 2023 — Nov 2023 [monthly]

    Active Not Recruiting EARLY_PHASE1

  3. Oct 2022 — Feb 2023 [monthly]

    Active Not Recruiting EARLY_PHASE1

  4. Jun 2022 — Oct 2022 [monthly]

    Active Not Recruiting EARLY_PHASE1

    Status: RecruitingActive Not Recruiting

  5. Apr 2022 — Jun 2022 [monthly]

    Recruiting EARLY_PHASE1

  6. Sep 2021 — Apr 2022 [monthly]

    Recruiting EARLY_PHASE1

    First recorded

Mar 2021

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Children's Hospital Colorado
  • Clara Inspired
  • Horizon Therapeutics
  • SLC6A1 Connect
  • STXBP1 Foundation
  • University of Pennsylvania Orphan Disease Center
  • Weill Medical College of Cornell University
Data source: Weill Medical College of Cornell University

For direct contact, visit the study record on ClinicalTrials.gov .