deltatrials
Terminated PHASE2 INTERVENTIONAL 1-arm NCT04964960

Pembro+Chemo in Brain Mets

Phase II Investigation of Use of CNS Active Pembrolizumab and Chemotherapy for Asymptomatic Brain Metastasis From Non-small Cell Lung Cancer (NSCLC)

Sponsor: John L. Villano, MD, PhD

Conditions Brain Cancer Cancer Lung Cancer Lung Cancer Metastatic
Interventions Carboplatin Nab paclitaxel Paclitaxel Pembrolizumab Pemetrexed
Updated 11 times since 2021 Last updated: Oct 14, 2025 Started: May 19, 2022 Primary completion: Jun 19, 2023 Completion: Dec 19, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Slow Accrual

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Listed as NCT04964960, this PHASE2 trial focuses on Brain Cancer and Cancer and remains terminated or withdrawn. Sponsored by John L. Villano, MD, PhD, it has been updated 11 times since 2022, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Feb 2022 · 3 months · monthly snapshot~Feb 2022 – ~Mar 2023 · 13 months · monthly snapshotRecruiting~Mar 2023 – ~Sep 2023 · 6 months · monthly snapshotRecruiting~Sep 2023 – ~Feb 2024 · 5 months · monthly snapshotRecruiting~Feb 2024 – ~May 2024 · 3 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Nov 2025 · 12 months · monthly snapshotTerminated~Nov 2025 – present · 10 months · monthly snapshotTerminated

Change History

11 versions recorded

  1. Nov 2025 — Present [monthly]

    Terminated PHASE2

  2. Nov 2024 — Nov 2025 [monthly]

    Terminated PHASE2

    Status: Active Not Recruiting → Terminated

  3. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  5. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

▶ Show 6 earlier versions

  1. Feb 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  2. Sep 2023 — Feb 2024 [monthly]

    Recruiting PHASE2

  3. Mar 2023 — Sep 2023 [monthly]

    Recruiting PHASE2

  4. Feb 2022 — Mar 2023 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  5. Nov 2021 — Feb 2022 [monthly]

    Not Yet Recruiting PHASE2

  6. Sep 2021 — Nov 2021 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • John L. Villano, MD, PhD
Data source: University of Kentucky

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations