deltatrials
Recruiting PHASE1 INTERVENTIONAL 2-arm NCT04995003

HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma

Phase I Study of HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma (HEROS 3.0)

Sponsor: Baylor College of Medicine

Updated 14 times since 2021 Last updated: Jan 21, 2026 Started: Dec 7, 2021 Primary completion: Jun 30, 2028 Completion: Jun 30, 2043
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Ewing Sarcoma and HER-2 Protein Overexpression and is currently actively recruiting participants. Baylor College of Medicine leads this study, which shows 14 recorded versions since 2021 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Jan 2023 · 12 months · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Jul 2023 · 4 months · monthly snapshot~Jul 2023 – ~Feb 2024 · 7 months · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Dec 2024 · 2 months · monthly snapshot~Dec 2024 – ~Dec 2025 · 12 months · monthly snapshot~Dec 2025 – ~Feb 2026 · 2 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

14 versions recorded
  1. Feb 2026 — Present [monthly]

    Recruiting PHASE1

  2. Dec 2025 — Feb 2026 [monthly]

    Recruiting PHASE1

  3. Dec 2024 — Dec 2025 [monthly]

    Recruiting PHASE1

  4. Oct 2024 — Dec 2024 [monthly]

    Recruiting PHASE1

  5. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE1

Show 9 earlier versions
  1. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  2. Feb 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

  3. Jul 2023 — Feb 2024 [monthly]

    Recruiting PHASE1

  4. Mar 2023 — Jul 2023 [monthly]

    Recruiting PHASE1

  5. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE1

  6. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE1

  7. Jan 2022 — Jan 2023 [monthly]

    Recruiting PHASE1

    Status: Not Yet RecruitingRecruiting

  8. Dec 2021 — Jan 2022 [monthly]

    Not Yet Recruiting PHASE1

  9. Sep 2021 — Dec 2021 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Baylor College of Medicine
  • Center for Cell and Gene Therapy, Baylor College of Medicine
  • National Cancer Institute (NCI)
  • St. Baldrick's Foundation
  • Stand Up To Cancer
  • The Faris Foundation USA
  • Triumph Over Kid Cancer Foundation
Data source: Baylor College of Medicine

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations