deltatrials
Unknown PHASE4 INTERVENTIONAL 2-arm NCT05005689

Fluoride Delivery to Prevent White Spots During Orthodontic Treatment (FL4OWS)

A Randomised, Controlled Trial to Assess the Effect of Different Modes of Fluoride Delivery on Enamel Demineralisation, During Orthodontic Treatment With Fixed Appliances

Sponsor: Liverpool University Hospitals NHS Foundation Trust

Conditions Orthodontic Appliance Complication Tooth Demineralization
Interventions Fluoride mouthwash (0.05%; 225ppm). Tooth Mousse Plus
Updated 7 times since 2021 Last updated: Nov 6, 2023 Started: Oct 20, 2023 Primary completion: Sep 30, 2025 Completion: Sep 30, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Orthodontic Appliance Complication and Tooth Demineralization and is currently ongoing. Liverpool University Hospitals NHS Foundation Trust leads this study, which shows 7 recorded versions since 2023 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Sep 2021 – ~Jul 2022 · 10 months · monthly snapshotNot Yet Recruiting~Jul 2022 – ~Dec 2022 · 5 months · monthly snapshotNot Yet Recruiting~Dec 2022 – ~Dec 2023 · 12 months · monthly snapshotNot Yet Recruiting~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2026 · 16 months · monthly snapshotRecruiting~Jan 2026 – present · 6 months · monthly snapshotUnknown

Change History

7 versions recorded

  1. Jan 2026 — Present [monthly]

    Unknown PHASE4

    Status: Recruiting → Unknown

  2. Sep 2024 — Jan 2026 [monthly]

    Recruiting PHASE4

  3. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE4

  4. Dec 2023 — Jul 2024 [monthly]

    Recruiting PHASE4

    Status: Not Yet Recruiting → Recruiting

  5. Dec 2022 — Dec 2023 [monthly]

    Not Yet Recruiting PHASE4

▶ Show 2 earlier versions

  1. Jul 2022 — Dec 2022 [monthly]

    Not Yet Recruiting PHASE4

  2. Sep 2021 — Jul 2022 [monthly]

    Not Yet Recruiting PHASE4

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Liverpool University Hospitals NHS Foundation Trust
Data source: Liverpool University Hospitals NHS Foundation Trust

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations