Terminated PHASE2 INTERVENTIONAL 1-arm NCT05012397

Milademetan in Advanced/Metastatic Solid Tumors

A Phase 2 Basket Study of Milademetan in Advanced/Metastatic Solid Tumors (MANTRA-2)

Sponsor: Rain Oncology Inc

Conditions Adrenocortical Carcinoma Biliary Tract Cancer Bladder Urothelial Carcinoma Breast Cancer Invasive Cervical Cancer Cholangiocarcinoma Gastric Cancer Head and Neck Carcinoma Lung Adenocarcinoma MDM2 Gene Amplification Melanoma Non Small Cell Lung Cancer Ovarian Carcinoma Pancreas Cancer Sarcoma Solid Tumors Stomach Adenocarcinoma Testicular Germ Cell Tumor

Interventions RAIN-32

Updated 18 times since 2021 Last updated: Oct 14, 2024 Started: Nov 1, 2021 Primary completion: Oct 15, 2023 Completion: Oct 15, 2023

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Sponsor Decision

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This PHASE2 trial investigates Adrenocortical Carcinoma and Biliary Tract Cancer and is currently terminated or withdrawn. Rain Oncology Inc leads this study, which shows 18 recorded versions since 2021 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

Change History

18 versions recorded

Sep 2025 — Present [monthly]

Terminated PHASE2
Nov 2024 — Sep 2025 [monthly]

Terminated PHASE2
Sep 2024 — Nov 2024 [monthly]

Terminated PHASE2
Jul 2024 — Sep 2024 [monthly]

Terminated PHASE2
Nov 2023 — Jul 2024 [monthly]

Terminated PHASE2

Status: Active Not Recruiting → Terminated

▶ Show 13 earlier versions

Sep 2023 — Nov 2023 [monthly]

Active Not Recruiting PHASE2

Status: Recruiting → Active Not Recruiting
May 2023 — Sep 2023 [monthly]

Recruiting PHASE2
Apr 2023 — May 2023 [monthly]

Recruiting PHASE2
Feb 2023 — Apr 2023 [monthly]

Recruiting PHASE2
Jan 2023 — Feb 2023 [monthly]

Recruiting PHASE2
Dec 2022 — Jan 2023 [monthly]

Recruiting PHASE2
Sep 2022 — Dec 2022 [monthly]

Recruiting PHASE2
Apr 2022 — Sep 2022 [monthly]

Recruiting PHASE2
Mar 2022 — Apr 2022 [monthly]

Recruiting PHASE2
Feb 2022 — Mar 2022 [monthly]

Recruiting PHASE2
Dec 2021 — Feb 2022 [monthly]

Recruiting PHASE2

Status: Not Yet Recruiting → Recruiting
Oct 2021 — Dec 2021 [monthly]

Not Yet Recruiting PHASE2
Sep 2021 — Oct 2021 [monthly]

Not Yet Recruiting PHASE2

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Rain Oncology Inc

Data source: Rain Oncology Inc

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Boston, United States , Cincinnati, United States , Durham, United States , Fort Myers, United States , Houston, United States , Nashville, United States , New York, United States , Palo Alto, United States , Sioux Falls, United States , St Louis, United States and 3 more locations