deltatrials
Terminated PHASE1/PHASE2 INTERVENTIONAL 2-arm NCT05313009

Tarlox and Sotorasib in Patients With KRAS G12C Mutations

A Phase Ib / II Trial of Tarloxotinib and Sotorasib in Patients With KRAS G12C Mutations

Sponsor: Medical University of South Carolina

Updated 8 times since 2022 Last updated: Nov 20, 2025 Started: Mar 7, 2022 Primary completion: Jul 7, 2023 Completion: Dec 31, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Study drug was discontinued by manufacturer for business reasons.

This PHASE1/PHASE2 trial investigates Non-Small Cell Lung Cancer and is currently terminated or withdrawn. Medical University of South Carolina leads this study, which shows 8 recorded versions since 2022 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~May 2022 – ~Dec 2022 · 7 months · monthly snapshotRecruiting~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Aug 2023 · 6 months · monthly snapshotRecruiting~Aug 2023 – ~Feb 2024 · 6 months · monthly snapshotActive Not Recruiting~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshotTerminated~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2026 · 16 months · monthly snapshotTerminated~Jan 2026 – present · 5 months · monthly snapshotTerminated

Change History

8 versions recorded
  1. Jan 2026 — Present [monthly]

    Terminated PHASE1/PHASE2

  2. Sep 2024 — Jan 2026 [monthly]

    Terminated PHASE1/PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1/PHASE2

    Phase: PHASE1_PHASE2PHASE1/PHASE2

  4. Feb 2024 — Jul 2024 [monthly]

    Terminated PHASE1_PHASE2

    Status: Active Not RecruitingTerminated

  5. Aug 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: RecruitingActive Not Recruiting

Show 3 earlier versions
  1. Feb 2023 — Aug 2023 [monthly]

    Recruiting PHASE1_PHASE2

  2. Dec 2022 — Feb 2023 [monthly]

    Recruiting PHASE1_PHASE2

  3. May 2022 — Dec 2022 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Mar 2022

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Medical University of South Carolina
  • Rain Oncology Inc
Data source: Medical University of South Carolina

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations