Entospletinib Plus Intensive Induction/Consolidation Chemotherapy in Newly Diagnosed NPM1-mutated AML
A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of Entospletinib in Combination With Intensive Induction and Consolidation Chemotherapy in Adults With Newly Diagnosed Nucleophosmin 1-mutated Acute Myeloid Leukemia
Sponsor: Kronos Bio
Terminated
Termination was due to significant challenges associated with study enrollment in a genetic subset of fit participants in the front-line acute myeloid leukemia (AML) setting and other challenges associated with post-COVID impacts.
Other terminated trials from Kronos Bio
More terminations from Kronos Bio
This PHASE3 trial investigates Nucleophosmin 1-mutated Acute Myeloid Leukemia and is currently terminated or withdrawn. Kronos Bio leads this study, which shows 20 recorded versions since 2021 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.
Status Flow
Change History
20 versions recorded-
Sep 2025 — Present [monthly]
Terminated PHASE3
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Sep 2024 — Sep 2025 [monthly]
Terminated PHASE3
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Jul 2024 — Sep 2024 [monthly]
Terminated PHASE3
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Feb 2024 — Jul 2024 [monthly]
Terminated PHASE3
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Jul 2023 — Feb 2024 [monthly]
Terminated PHASE3
Status: Active Not Recruiting → Terminated
▶ Show 15 earlier versions
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May 2023 — Jul 2023 [monthly]
Active Not Recruiting PHASE3
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Apr 2023 — May 2023 [monthly]
Active Not Recruiting PHASE3
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Mar 2023 — Apr 2023 [monthly]
Active Not Recruiting PHASE3
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Feb 2023 — Mar 2023 [monthly]
Active Not Recruiting PHASE3
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Dec 2022 — Feb 2023 [monthly]
Active Not Recruiting PHASE3
Status: Recruiting → Active Not Recruiting
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Nov 2022 — Dec 2022 [monthly]
Recruiting PHASE3
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Sep 2022 — Nov 2022 [monthly]
Recruiting PHASE3
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Jun 2022 — Sep 2022 [monthly]
Recruiting PHASE3
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May 2022 — Jun 2022 [monthly]
Recruiting PHASE3
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Apr 2022 — May 2022 [monthly]
Recruiting PHASE3
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Mar 2022 — Apr 2022 [monthly]
Recruiting PHASE3
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Feb 2022 — Mar 2022 [monthly]
Recruiting PHASE3
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Jan 2022 — Feb 2022 [monthly]
Recruiting PHASE3
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Dec 2021 — Jan 2022 [monthly]
Recruiting PHASE3
Status: Not Yet Recruiting → Recruiting
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Sep 2021 — Dec 2021 [monthly]
Not Yet Recruiting PHASE3
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- Kronos Bio
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
Angers, France , Ann Arbor, United States , Ashdod, Israel , Badalona, Spain , Barcelona, Spain , Bari, Italy , Be’er Ya‘aqov, Israel , Bologna, Italy , Braunschweig, Germany , Brno, Czechia and 56 more locations