deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 3-arm NCT05107219

GCC Agonist Signal in the Small Intestine

Pilot Study of GCC Agonists to Identify a Cyclic-GMP Signal in Duodenal Tissue of Volunteers

Sponsor: National Cancer Institute (NCI)

Updated 15 times since 2021 Last updated: Dec 12, 2025 Started: Nov 30, 2022 Primary completion: Feb 28, 2026 Completion: Feb 28, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Barrett Esophagus and Gastroesophageal Reflux Disease, this trial is ongoing. The trial is conducted by National Cancer Institute (NCI) and has accumulated 15 data snapshots since 2022. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Dec 2021 – ~Feb 2022 · 2 months · monthly snapshot~Feb 2022 – ~Jun 2022 · 4 months · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Oct 2022 · 30 days · monthly snapshot~Oct 2022 – ~Nov 2022 · 31 days · monthly snapshot~Nov 2022 – ~Nov 2023 · 12 months · monthly snapshot~Nov 2023 – ~May 2024 · 6 months · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jun 2025 · 9 months · monthly snapshot~Jun 2025 – ~Nov 2025 · 5 months · monthly snapshot~Nov 2025 – ~Jan 2026 · 2 months · monthly snapshot~Jan 2026 – present · 6 months · monthly snapshot

Change History

15 versions recorded
  1. Jan 2026 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Nov 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE1

  3. Jun 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

  4. Sep 2024 — Jun 2025 [monthly]

    Recruiting PHASE1

  5. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

Show 10 earlier versions
  1. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

  2. May 2024 — Jun 2024 [monthly]

    Recruiting PHASE1

  3. Nov 2023 — May 2024 [monthly]

    Recruiting PHASE1

    Phase: EARLY_PHASE1PHASE1

  4. Nov 2022 — Nov 2023 [monthly]

    Recruiting EARLY_PHASE1

    Status: Not Yet RecruitingRecruiting

  5. Oct 2022 — Nov 2022 [monthly]

    Not Yet Recruiting EARLY_PHASE1

  6. Sep 2022 — Oct 2022 [monthly]

    Not Yet Recruiting EARLY_PHASE1

  7. Jul 2022 — Sep 2022 [monthly]

    Not Yet Recruiting EARLY_PHASE1

  8. Jun 2022 — Jul 2022 [monthly]

    Not Yet Recruiting EARLY_PHASE1

  9. Feb 2022 — Jun 2022 [monthly]

    Not Yet Recruiting EARLY_PHASE1

  10. Dec 2021 — Feb 2022 [monthly]

    Not Yet Recruiting EARLY_PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
  • University of Wisconsin, Madison
Data source: University of Wisconsin, Madison

For direct contact, visit the study record on ClinicalTrials.gov .