deltatrials
Terminated PHASE3 INTERVENTIONAL 3-arm NCT05142904

Radiofrequency Ablation Versus I-131 for Solitary Autonomous Thyroid Nodules (RABITO)

Ultrasound-guided Radiofrequency Ablation Versus Radioactive Iodine as Treatment for Hyperthyroidism Caused by Solitary Autonomous Thyroid Nodules

Sponsor: Amsterdam UMC

Updated 8 times since 2022 Last updated: Jul 14, 2025 Started: Nov 17, 2021 Primary completion: Nov 1, 2024 Completion: Nov 1, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Switched from RCT to observational prospective cohort due to termination of subsidy (delay due to insufficient inclusion-rate). Follow-up of RCT-arm will be completed. Patients can still be included in a observational cohort.

A PHASE3 clinical study on Autonomous Thyroid Function and Iodine Adverse Reaction, this trial is terminated or withdrawn. The trial is conducted by Amsterdam UMC and has accumulated 8 data snapshots since 2021. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jan 2022 – ~Mar 2022 · 59 days · monthly snapshotRecruiting~Mar 2022 – ~May 2023 · 14 months · monthly snapshotRecruiting~May 2023 – ~May 2024 · 12 months · monthly snapshotRecruiting~May 2024 – ~Jul 2024 · 2 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Aug 2025 · 11 months · monthly snapshotRecruiting~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshotTerminated~Sep 2025 – present · 7 months · monthly snapshotTerminated

Change History

8 versions recorded
  1. Sep 2025 — Present [monthly]

    Terminated PHASE3

  2. Aug 2025 — Sep 2025 [monthly]

    Terminated PHASE3

    Status: RecruitingTerminated

  3. Sep 2024 — Aug 2025 [monthly]

    Recruiting PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE3

  5. May 2024 — Jul 2024 [monthly]

    Recruiting PHASE3

Show 3 earlier versions
  1. May 2023 — May 2024 [monthly]

    Recruiting PHASE3

  2. Mar 2022 — May 2023 [monthly]

    Recruiting PHASE3

  3. Jan 2022 — Mar 2022 [monthly]

    Recruiting PHASE3

    First recorded

Nov 2021

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Amsterdam UMC
  • Rijnstate Hospital
  • University of Twente
  • ZonMw: The Netherlands Organisation for Health Research and Development
Data source: Rijnstate Hospital

For direct contact, visit the study record on ClinicalTrials.gov .